Avirulent microbes and uses therefor

Details Avirulent microbes and uses therefor Avirulent microbes and uses therefor

1994-03-10

1999-01-05

Scheiner, Laurie

Drug, bio-affecting and body treating compositions

In vivo diagnostic or in vivo test agent which contains an...

424 9348, 4241841, 4242001, 4242351, 4242571, 4242581, 4351723, 4352523, 43525233, 4353201, 435879, A61K 3902, A61K 39112, C12N 121

Patent

active

058558799

ABSTRACT:
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.

REFERENCES:
patent: 4190495 (1980-02-01), Curtis
patent: 4837151 (1989-06-01), Stocker
Komeda et al. Molec. Gen. Genet. vol. 142, 289-298 (1975).
Ferrari et al. Biotechnology, vol. 3, Nov. 1985, pp. 1003-1007.
Jagusztyn-Krynicka et al., Journal of General Microbiology (1982) pp. 1135-1145.

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