Avirulent microbes and uses therefor

Details Avirulent microbes and uses therefor Avirulent microbes and uses therefor

1992-10-22

1995-02-14

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 934, 424 931, 4353201, 4351723, 935 72, 935 73, A61K 39112, A61K 39108

Patent

active

053893689

ABSTRACT:
This invention provides a vaccine for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and cyclic AMP receptor protein. The invention also provides a vaccine for the immunization of a vertebrate and invertebrate comprising a virulent derivative of a pathogenic microbe said derivative being substantially incapable of producing functional adenylate cyclase and cyclic AMP receptor protein while being capable of expressing a recombinant gene derived from a pathogen of said vertebrate to produce and antigen capable of inducing an immune response in said vertebrate against said pathogen.

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