Avirulent herpetic viruses useful as tumoricidal agents and vacc

Details Avirulent herpetic viruses useful as tumoricidal agents and vacc Avirulent herpetic viruses useful as tumoricidal agents and vacc

1996-07-24

1998-10-20

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424573, 435239, A61K 39245, C12N 702

Patent

active

058243186

ABSTRACT:
Isolated tumoricidal herpetic viruses, in particular neurotrophic herpes viruses, T-lymphotrophic viruses, and B-lymphotrophic viruses, which are avirulent and capable of selectively replicating in and destroying neoplastic cells, and pharmaceutical compositions, vaccines, and methods of destroying neoplastic cells employing the isolated tumoricidal herpetic viruses are described. A method of isolating tumoricidal herpetic viruses by sequentially passaging attenuated, avirulent herpetic viruses on neoplastic cells which fail to support replication of the herpetic viruses and isolating the viruses which grow on the neoplastic cells is also described. Herpes simplex virus mutants having a genome from which the .gamma.34.5 genes have been deleted and which require at least one additional mutation to produce a non-neurovirulent herpes simplex virus which selectively replicates in and destroys neoplastic cells are also described.

REFERENCES:
patent: 5328688 (1994-07-01), Roizman
Chou, J. et al., Proc. Natl. Acad. Sci. USA, vol. 89, pp. 3266-3270 (1992).
Chou, J. et al., Science, vol. 250, pp. 1262-1266 (1990).
Markert J. et al. Neurosurgery, vol. 32, No. 4, pp. 597-603, Apr. 1993.
Chambers, R., et al., Proc. Nat'l. Acad. Sci. USA, 92:1411-1415 (1995).

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