Avirulent anti-rabies vaccine

Details Avirulent anti-rabies vaccine Avirulent anti-rabies vaccine

1997-01-17

1998-12-29

Smith, Lynette F.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 4241841, 4242241, 4351721, 4351731, 435 691, 435239, C12N 1500, C12P 2106, A61K 3921, A61K 39205

Patent

active

058537350

ABSTRACT:
The invention relates to an avirulent anti-rabies vaccine which consists of an avirulent mutant of an SAD strain of the rabies virus, the glycoprotein of which possesses in position 333 a naturally occurring amino acid whose codon differs from those of arginine by at least two nucleotides.

REFERENCES:
Seif, et al, 1985, "Rabies Virulence: Effect on Pathogenicity . . . " J. of Virol. 53(3): 926-934.
Tuffereau, et al, 1889, "Arginine or Lysine in Position 333 . . . " Virology 172:206-212.
Immunochemistry Abstract 105:4059s. "Avirulent Mutants of Rabies Virus . . . ".
Coulon, et al, 1982, "Molecular Basis of Rabies Virus Virulence . . . " J. Gen. Virol. 61:97-100.
Tidke, et al, 1987, "Characterization of a Double Avirulent Mutant . . . " Vaccine 5(3):229-233.
Pepin et al., Ann. Inst. Pasteur Virol 136(1), 1985.
Yelverton et al., Science vol. 219, p. 614, 1983.
Tidke et al., Vaccine 5 (3), 1987, pp. 229-233.
P. Coulon et al., J. Gen. Virol., vol. 61, pp. 97-100, 1982.
15-Immunochemistry Abstract, vol. 106, 1986, 105:4059s Avirulent Mutants of Rabies Virus: Change in the Site III of the Glycoprotein.
3-Biochem. Genetics, vol. 102, 1985, 102:143960y Rabies Virulence: Effect on Pathogenicity and Sequence Characterization of Rabies Virus Mutations Affecting Antigenic Site III of the Glycoprotein.
Virology, vol. 172, 1989, New York, USA, pp. 206-212, Tuffereau et al., "Arginine of Lysine in Position 333 of Era and CVS Glycoprotein is Necessary for Rabies Virulence in Adult Mice".
Proceedings of the National Academy of Sciences, USA, vol. 80, 1983, Washington, D.C., USA, pp. 70-74, Dietzschold et al., "Characterization of an Antigenic Determinant of the Glycoprotein that Correlates with Pathogenicity of Rabies Virus".

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