Avidin or streptavidin conjugated liposomes

Details Avidin or streptavidin conjugated liposomes Avidin or streptavidin conjugated liposomes

1987-06-09

1990-08-14

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

530399, 530403, 530404, 530405, 530406, 424455, 436829, A61K 3722, C08H 100

Patent

active

049485903

ABSTRACT:
A liposome conjugated with a streptavidin compound, wherein carboxyl residues of the streptavidin are coupled to phospholipid amino groups of the liposome. The resultant streptavidin-conjugated liposome can be used to encapsulate drugs and cytotoxic agents for site-specific in vivo or ex corpra targeting.

REFERENCES:
patent: 4762915 (1988-08-01), Kung et al.
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Buckel et al., "Purification, Characterization and Reconstruction of Glutaconyl-CoA Decarboxylase, a Biotin-Dependent Sodium Pump from Anaerobic Bacteria", Eur. J. Biochem., vol. 136, pp. 427-434, (1983).
Urdal et al., "Tumor-Associated Ganglio-N-Triosylceramide-Target for Antibody-Dependent, Avidin-Mediated Drug Killing of Tumor Cells", Journal of Biological Chemistry, vol. 255, No. 21, pp. 10509-10516, 1980.
Fraley et al., "Liposome-Medicated Delivery of Deoxyribonucleic Acid to Cells: Engaged Efficiency of Delivery Related to Lipid Composition and Incubation Conditions", Biochemistry, vol. 20, pp. 6978-6987, 1981.
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Mayhew et al., "Therapeutic Application of Liposomes", Liposomes, (M. J. Ostro, ed.), pp. 289-341, Marcel Dekker, Inc., New York, 1983.
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V. O. Ivanov, S. N. Preobrazrazhensky, V. P. Tsibulsky, V. R. Babaev, V. S. Repin and V. N. Smirnov, "Liposome Uptake by Cultured Macrophages Mediated by Modified Low-Density Lipoproteins", Biochim. Biophys. Acta, 846, 76-84, (1985).
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M. B. Rosenberg, E. Hawrot and X. O. Breakefield, "Receptor Binding Activities of Biotinylated Derivatives of Beta-Nerve Growth Factor", J. Neurochem., 46, 641-648, (1986).
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