Avidin dimers effective in increasing the concentration of...

Details Avidin dimers effective in increasing the concentration of... Avidin dimers effective in increasing the concentration of...

2008-07-03

2010-10-05

Jones, D L (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

C424S001110, C424S001650, C424S130100, C424S178100, C206S223000, C206S569000, C206S570000

Reexamination Certificate

active

07807133

ABSTRACT:
Dimers of avidin and streptavidins (diavidins) are described wherein the linker is suberate, which in turn, is bound to different functional groups (—NH2 o-COOH) of avidin. As compared to avidin, the diavidins have shown the ability to increase the amount of labelled biotin on the target, when used in an in vitro pretargeting test using supported human tenascin, the biotinylated anti-tenascin monoclonal antibody (Mab-B), avidin/diavidin, and biotin-3H. The use of such diavidins is also described in cancer diagnosis and anticancer therapy based on the three-step pretargeted radioimmunotherapy procedure.

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International Search Report for PCT/IT03/00135 dated Oct. 7, 2003.

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