Avidin derivatives and uses thereof

Details Avidin derivatives and uses thereof Avidin derivatives and uses thereof

2007-05-15

2007-05-15

Ceperley, Mary E. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

C435S007500, C436S525000, C436S527000, C530S391300

Reexamination Certificate

active

10624503

ABSTRACT:
A covalent conjugate of a 4′-hydroxyazobenzene-2-carboxylic acid derivative (HABA) and an avidin-type molecule, of the formula:wherein A is (CH2)nor —CH═CH—, wherein n is an integer from 0–10; B is (CH2)nwherein n is an integer from 2 to 10; m is zero or 1; and Av is the residue of an avidin-type molecule selected from the group comprising native egg-white avidin, recombinant avidin, deglycosylated avidins, bacterial streptavidin, recombinant streptavidin, truncated streptavidin and other derivatives of said avidin-type molecules. These HABAylated avidins are red colored in the quinone configuration and can be used in many applications in the avidin-biotin technology.

REFERENCES:
patent: 5182203 (1993-01-01), Ebersole et al.
patent: WO 97/00329 (1997-03-01), None
Morpurgo et al (1998), “A Chemical Approach To Illustrate the Principle of Signal Transduction Cascades Using the Avidin—Biotin System”,J. Am. Chem. Soc., 120:12734-12739.
Tsurui Hironori, “PEG-Modified Avidin and Method for Separating Antigen or Antibody Using the Same”,Patent Abstracts of Japan, Publ. No. 08012699, Publ. Date Jan. 16, 1996; vol. 1996, No. 5, May 31, 1996.
Green, M. “Avidin and Streptavidin”,Methods in Enzymology, US, Academic Press Inc., San Diego, CA, vol. 184, Jan. 1, 1990, pp. 51-67.

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