Avian recombinant live vaccine using, as vector, the avian infec

Details Avian recombinant live vaccine using, as vector, the avian infec Avian recombinant live vaccine using, as vector, the avian infec

1998-12-23

2000-11-28

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

4352351, 4353201, 4242291, 424816, 424 932, A61K 3912, C12N 701, C12N 1538, C12N 1586

Patent

active

061531995

ABSTRACT:
The living recombinant avian vaccine comprises, as a vector, an ILTV virus comprising and expressing at least one heterologous nucleotide sequence, this nucleotide sequence being inserted in the insertion locus defined between the nucleotides 1624 and 3606 at the SEQ ID NO: 5. The vaccine may in particular comprise a sequence coding for an antigen of an avian pathogenic agent selected among the group consisting of the Newcastle disease virus (NDV), the infections bursal virus (IBDV), the Marek disease virus (MDV), the infectious bronchitis virus (IBV), the chicken anaemia virus (CAV), thee chicken pneumovirosis virus, preferably under the control of a strong eukariotic promoter. A multivalent vaccine formula is also disclosed.

REFERENCES:
patent: 5733554 (1998-03-01), Audonnet et al.
Kingsley et al, Virology 203:336-343, 1994.
Wilson et al, Virology 199:393-402, 1994.
A.M. Griffin, "Identification of 21 Genes of Infectious Laryngotracheitis Virus Using Random Sequencing of Genomic DNA", J. Gen Viro l, vol. 70 (1989) pp. 3085-3089.
M.A. Johnson, et al, "Gallid Herpesvirus 1 (Infectious Laryngotracheitis Virus): Cloning and Physical Maps of the SA-2 Strain", Archives of Virology, vol. 119 (1991) pp. 181-198.
Martha A. Wild, et al, "A Genomic Map of Infectious Laryngotracheitis Virus and The Sequence and Organization of Genes Present In The Unique Short and Flanking Regions", Virus Genes, vol. 12:2 (1996) pp. 107-116.

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