Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1987-12-04
1991-02-26
Schwartz, Richard A.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351721, 4352351, 435237, 4353201, 536 27, C12N 1503
Patent
active
049961527
ABSTRACT:
DNA fragments (seeds) having the characteristics of amplicons, which are useful for amplifying genes of interest, have been isolated from Marek's disease viruses of poultry. Concatmers of the seeds and the associated genes have potential as vaccines or delivery vectors when cotransfected and replicated in the presence of helper viruses. The amplicons are also useful for inserting associated genes into the helper viruses, which in turn could be used as expression vectors. Candidate genes for use with the subject amplicons include those which encode immunogenic proteins and other beneficial economic traits desired in commercial poultry lines.
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Maotani et al. (1986), Amplification of a TDR etc., J. Virol. 58 (2) 657-660.
Kwong and Frenkel (1985), HSV Amplicon-IV Efficient Expression, etc., Virology 142 421-5.
Frenkel (1981), Defective Interfering Herpesviruses, Chapter in Human Herpesviruses Ed. by Nahmias et al., Elsevier, 1981 pp. 91-120.
Spaete et al. (1985), HSV Amplicon: Analysis etc., P.N.A.S. 82 694-8.
Yates et al. (1985), Stable Replication of etc., Nature 313 812-815.
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Spaeke and Frenkel (1982), HSV Amplicon: A New . . . Vector, Cell 30 295-304.
R. R. Spaete et al., "The Herpes Simplex Virus Amplicon: A New Eucaryotic Defective-Virus Cloning-Amplifying Vector," Cell 30: 295-304 (Aug. 1982).
A. D. Kwong et al., "Herpes Simplex Virus Amplicon: Effect of Size on Replication of Constructed Defective Genomes Containing Eucaryotic DNA Sequences," J. Virol. 51 (3): 595-603 (Sep. 1984).
A. D. Kwong et al., "The Herpes Simplex Virus Amplicon. IV. Efficient Expression of a Chimeric Chicken Ovalbumin Gene Amplified Within Defective Virus Genomes," Virology 142: 421-425 (1985).
Carter Jeanne K.
Silva Robert F.
Fado John D.
Ribando Curtis P.
Schwartz Richard A.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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