Drug – bio-affecting and body treating compositions – Lymphokine – Interleukin
Reexamination Certificate
2008-03-25
2008-03-25
Landsman, Robert (Department: 1646)
Drug, bio-affecting and body treating compositions
Lymphokine
Interleukin
C530S351000, C514S002600
Reexamination Certificate
active
07347996
ABSTRACT:
Embodiments of the present invention generally relate to novel avian cytokines, to DNA sequences encoding these novel cytokines and to their use in adjuvants for vaccine purposes.
REFERENCES:
patent: 199713859 (1997-04-01), None
patent: 2003024354 (2003-03-01), None
Mickle, JE and Cutting GR. Genotype-phenotype relationships in cystic fibrosis. Med. Clin. North Am. 2000. vol. 84, No. 3, p. 597-607.
Altschul, S.F., et al. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Research, 25(17), 3389-3402.
Belke, G. et al. (1996). Induction and detection of mRNA, molecular cloning and sequencing of canine interleukin. Veterinary Immunology and Immunopathology, 54(153).
Berman, P.W., et al. (Nov. 4, 1983). Detection of Antibodies to Herpes Simplex Virus with a Continuous Cell Line Expressing Cloned Glycoprotein D. Science, New Series, 222(4623), 524-527.
Brinster, R.L. et al. (Mar. 4, 1982). Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature, 296: 39-42.
Bush, K., et al. (1994). Molecular cloning of feline interleukin 12 p35 reveals the conservation of leucine-zipper motifs present in human and murine IL-12 p35. Molecular Immunology, 31(17), 1373-1374.
Carr, J.A. et al. (1999). The Role of Endogenous Interleukin-12 in Resistance to Murine Cytomegalovirus (MCMV) Infection and a Novel Action for Endogenous IL-12 p40. Journal of Interferon and Cytokine Research, 19:1145-1152.
de Goër de Herve, M. G. et al. (Apr. 21, 2001), Following direct CD40 activation, human primary microglial cells produce IL-12 p40 but not bioactive IL-12 p70. CYTOKINE, 14(2), 88-96.
Decken, K. et al. (Oct. 1998). Interleukin-12 is essential for a protective Th1 response in Mice infected withCryptococcus neoformans. Infection and Immunity, 66(10), 4994-5000.
Ding, A.H. (Oct. 1, 1988). Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. The Journal of Immunology, 141(7), 2407-2412.
Elkins, K.L. et al. (Apr. 2002). In vivo clearance of an intracellular bacterium,Francisella tularensisLVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infection and Immunity, 70(4), 1936-1948.
Foss, D.L. et al. (1997). Molecular cloning and mRNA expression of porcine interleukin-12. Veterinary Immunology and Immunopathology, 57: 121-134.
Gorman, C.M. et al. (Nov. 1982). The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proceedings of the National Academy of Sciences, 79: 6777-6781.
Heinzel, F.P. et al. (May 1997). In vivo production and function of IL-12 p40 homodimers. The Journal of Immunology, 158:4381-4388.
Henikoff, S. et al. (Nov. 1992). Amino acid substitution matrices from protein blocks. Proceedings of the National Academy of Sciences, 89: 10915-10919.
Hilton, L. S. et al. (2002). The emerging role of avian cytokines as immunotherapeutics and vaccine adjuvants. Veterinary Immunology and Immunopathology, 85:119-128.
Hölscher, C. et al. (Dec. 2001). A protective and agonistic function of IL-12p40 in mycobacterial infection. The Journal of Immunology, 167:6957-6966.
Lehmann, J. et al. (Nov. 2001). IL-12p40-Dependent Agonistic Effects on the Development of Protective Innate and Adaptive Immunity Against Salmonella Enteritidis. The Journal of Immunology, 167:5304-5315.
Lipman, D. J. et al. (Mar. 22, 1985). Rapid and sensitive protein similarity searches. Science, 227:1435-1441.
Lowenthal, J. W. (2000). Avian cytokines-the natural approach to therapeutics. Developmental & Comparative Immunology, 24:355-365.
Mattner, F. et al. (Nov. 1997). Treatment with Homodimeric Interleukin-12 (IL-12) p40 Protects Mice from IL-12-Dependent Shock but not from tumor necrosis factor alpha-dependent shock. Infection and Immunity, 65(11), 4734-4737.
Mettenleiter, T. C. et al. (1990). A glycoprotein gX-B-galactosidase fusion gene as insertional marker for rapid identification of pseudorabies virus mutants. Journal of Virological Methods, 30:55-65.
Nagai, A. et al. (May 1991). Structural and functional conservation of histidinol dehydrogenase between plants and microbes. Proceedings of the National Academy of Sciences, 88:4133-4137.
Needleman, S. B. et al. (1970). A General Method Applicable to the Search for Similarities in the Amino Acid Sequence of Two Proteins. Journal Molecular Biology, 48:443-453.
Oppmann, B. et al. (Nov. 2000). Novel p19 protein engages IL-12p40 to form a cytokine, IL-23 with biological activities similar as well as distinct from IL-12. Immunity, 13:715-725.
Piccotti, J. R. et al. (Jan. 1997). Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-γ-Producing Cells. The Journal of Immunology, 158:643-648.
Staeheli, P. et al. (2001). Cytokines of Birds: Conserved functions-a largely different look. Journal of Interferon and Cytokine Research. 21:993-1010.
Stuehr, D. J. et al. (May 1989). Nitric Oxide A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. The Journal of Experimental Medicine, 169:1543-1555.
Trinchieri, G. (Dec. 15, 1994). Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of t-helper cells type 1 and cytotoxic lymphocytes. Blood, 84(12), 4008-4027.
Voellmy, R. et al. (Aug. 1985). Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment. Proceedngs of the National Academy of Sciences, 82:4949-4953.
Wiekowski, M.T. et al. (2001). Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. The Journal of Immunology, 166:7563-7570.
Wolf, S. F., et al. (May 1, 1991). Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. The Journal of Immunology, 146(9), 3074-3081.
Yoshimoto, T. et al. (1996). Molecular cloning and characterization of murine IL-12 genes. The Journal of Immunology, 156:1082-1088.
Gately, M. K. et al. (1995). Measurement of Human and Mouse Interleukin-12. Current Protocols in Immunity, Supplement 15, Unit 6.16.
Dayhoff, Margaret O. (1978). Atlas of Protein Sequence and Structure. vol. 5:Supplement 3. Publisher: National Biomedical Research Foundation, Washington, DC.
Rodriguez, Raymond L. and Denhardt, David T., (Oct. 1987). VECTORS A Survey of Molecular Cloning Vectors and Their Uses. Publisher: Butterworth-Heinemann, Stoneham, MA.
Ausubel, Frederick M. (1989). Current protocols in molecular biology. Publisher: Greene Publishing Associates, Brooklyn, N.Y.
Glover, D.M. and Hames, B.D. (1996). DNA Cloning, vols. 1-4, edition 1995. Publisher: Oxford University Press, USA.
Degen Wilhelmus Gerardus Johannes
Schijns Virgil Elisabeth Joseph Caspar
Blackstone William M.
Hissong Bruce D.
Intevert International B.V.
Landsman Robert
UD Technology Corporation
LandOfFree
Avian cytokines, such as IL-12, comprising a p40 and/or p35... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Avian cytokines, such as IL-12, comprising a p40 and/or p35..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avian cytokines, such as IL-12, comprising a p40 and/or p35... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2791360