Avian antitoxins to clostridium difficle toxin A

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds bacterium or component thereof or substance produced...

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5303895, 5303891, 4241641, 4241571, A61K 39395, C07K 1602, C07K 1612

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active

056018231

ABSTRACT:
The present invention includes methods and compositions for treating humans and other animals intoxicated with at least one Clostridial toxin by administration of antitoxin. In particular, the antitoxin directed against these toxins is produced in avian species. This avian antitoxin is designed so as to be orally administerable in therapeutic amounts and may be in any form (i.e., as a solid or in aqueous solution).

REFERENCES:
patent: 5080895 (1992-01-01), Tokoro
patent: 5196193 (1993-03-01), Carroll
Schmidt, J. Vet. Med., 36:619, 1989.
P. H. A. Sneath et al., "Clostridium," Bergey's Manual.RTM. of Systematic Bacteriology, vol. 2, pp. 1141-1200, Williams & Wilkins (1986).
P. G. Engelkirk et al., "Classification", Principles and Practice of Clinical Anaerobic Bacteriology, pp. 22-23, Star Publishing Co., Belmont, CA (1992).
J. Stephen and R. A. Petrowski, "Toxins Which Traverse Membranes and Deregulate Cells," in Bacterial Toxins, 2d ed., pp. 66-67, American Society for Microbiology (1986).
R. Berkow and A. J. Fletcher (eds.), "Bacterial Diseases," Merck Manual of Diagnosis and Therapy, 16th ed., pp. 119-126, Merck Research Laboratories, Rahway, N.J. (1992).
O. H. Siegmund and C. M. Fraser (eds.), "Clostridial Infections," Merck Veterinary Manual, 5th ed., pp. 396-409, Merck & Co., Rahway, N.J. (1979).
C. L. Hatheway, "Toxigenic Clostridia," Clin. Microbiol. Rev. 3:66-98 (1990).
S. Arnon, "Infant Botulism: Anticipating the Second Decade," J. Infect. Dis. 154:201-206 (1986).
S. Arnon, "Infant Botulism," Ann. Rev. Med. 31:541 (1980).
K. L. MacDonald et al., "The Changing Epidemiology of Adult Botulism in the United States," Am. J. Epidemiol. 124:794 (1986).
C. O. Tacket et al., "Equine Antitoxin Use and Other Factors That Predict Outcome in Type A Foodborne Botulism," Am. J. Med. 76:794 (1984).
M. N. Swartz, "Anaerobic Spore-Forming Bacilli: The Clostridia," pp. 633-646, in B. D. Davis et al., (eds.), Microbiology, 4th edition, J. B. Lippincott Co. (1990).
S. Arnon et al., "Infant Botulism: Epidemiology and Relation to Sudden Infant Death Syndrome," Epidemiol. Rev. 3:45 (1981).
T. L. Frankovich and S. Arnon, "Clinical Trial of Botulism Immune Globulin for Infant Botulism," West. J. Med. 154:103 (1991).
M. Balady, "Botulism Antitoxin Fielded for Operation Desert Storm," USAMRDC Newsletter, p. 6 (1991).
P. J. Schwarz and S. S. Arnon, "Botulism Immune Globulin for Infant Botulism Arrives-One Year and A Gulf War Later," Western J. Med. 156:197 (1992).
D. R. Peterson et al., "The Sudden Infant Death Syndrome and Infant Botulism," Rev. Infect. Dis. 1:630 (1979).
S. Arnon et al., "Intestinal Infection and Toxin Production by Clostridium Botulinum as One Cause of Sudden Infant Death Syndrome," Lancet, pp. 1273-1276, Jun. 17, 1978.
G. F. Brooks et al., (eds.) "Infections Caused by Anaerobic Bacteria," Jawetz, Melnick, & Adelberg's Medical Microbiology, 19th ed., pp. 257-262, Appleton & Lange, San Mateo, CA (1991).
P. G. Engelkirk et al., Principles and Practice of Clinical Anaerobic Bacteriology, pp. 64-67, Star Publishing Co., Belmont, CA (1992).
D. M. Lyerly et al., "Characterization of Toxin A-Negative, Toxin B-Positive Strain of Clostridium difficile," Infect. Immun. 60:4633 (1992).
S. P. Borriello et al., "Virulence Factors of Clostridium difficile," Rev. Infect. Dis., 12(suppl. 2):S185 (1990).
D. M. Lyerly et al., "Effects of Clostridium difficile Toxins Given Intragastrically to Animals," Infect. Immun., 47:349 (1985).
R. D. Rolfe, "Binding Kinetics of Clostridium difficile Toxins A and B to Intestinal Brush Border Membranes from Infant and Adult Hamsters," Infect. Immun., 59:1223 (1990).
Banno et al., "Biochemical Characterization and Biologic Actions of Two Toxins (D-1 and D-2) from Clostridium difficile," Rev. Infect. Dis., 6(Suppl. 1:S11-S20 (1984).
Rihn et al., "A New Purification Procedure for Clostridium Difficile Enterotoxin," Biochem. Biophys. Res. Comm., 124:690-695 (1984).
Justus et al., "Myoelectric Effects of Clostridium difficile: Motility-Altering Factors Distinct from its Cytotoxin and Enterotoxin in Rabbits," Gastroenterol., 83:836-843 (1982).
S. M. Finegold et al., "Antimicrobial-Associated Pseudomembranous Colitis," Clinical Guide to Anaerobic Infections, pp. 88-89, Star Publishing Co., Belmont, CA (1992).
H. N. Benson et al., "Requirement of Avian C'1 for Fixation of Guinea Pig Complement by Avian Antibody-Antigen Complexes," J. Immunol. 87:616 (1961).
A. A. Benedict and K. Yamaga, "Immunoglobulins and Antibody Production in Avian Species," in Comparative Immunology (J. J. Marchaloni, ed.), pp. 335-375, Blackwell, Oxford (1966).
R. Patterson et al., "Antibody Production and Transfer to Egg Yolk in Chickens," J. Immunol. 89:272 (1962).
S. B. Carroll and B. D. Stollar, "Antibodies of Calf Thymus RNA Polymerase II from Egg Yolks of Immunized Hens," J. Biol. Chem. 258:24 (1983).
A. Polson et al., "Antibodies to Proteins from Yolk of Immunized Hens," Immunol. Comm. 9:495 (1980).
M. Delmee et al., "Characterization of Flagella of Clostridium difficile and Their Role in Serogrouping Reactions," J. Clin. Microbiol., 28(10):2210 (1990).
M. Delmee and V. Avesani, "Virulence of Ten Serogroups of Clostridium difficile in Hamsters," J. Med. Microbiol., 33:85-90 (1990).
S. Toma et al., "Serotyping of Clostridium difficile," J. Clin. Microbiol., 26(3):426 (1988).
M. Delmee et al., "Serogrouping of Clostridium difficile Strains by Slide Agglutination," J. Clin. Microbiol., 21:323 (1985).
H. A. Davies and S. P. Boriello, "Detection of Capsule in Strains of Clostridium difficile of Varying Virulence and Toxigenicity," Microbial Path., 9:141 (1990).
M. A. C. Edelstein, "Processing Clinical Specimens for Anaerobic Bacteria: Isolation and Identification Procedures," in S. M. Finegold et al (eds.)., Bailey and Scott's Diagnostic Microbiology, pp. 477-507, C. V. Mosby Co., (1990).
N. V. Padhye et al., "Production and Characterization of a Monoclonal Antibody Specific for Enterohemorrhagic Escherichia coli of Serotypes 0157:H7 and 026:H11," J. Clin. Microbiol. 29:99-103 (1990).
D. M. Lyerly et al., "Passive Immunization of Hamsters Against Disease Caused by Clostridium difficile by Use of Bovine Immunoglobulin G Concentrate," Infect. Immun., 59:2215-2218 (1991).
B. R. DasGupta & V. Sathyamoorthy, "Purification and Amino Acid Composition of Type A Botulinum Neurotoxin," Toxicon, 22:415 (1984).
B. R. Singh & B. R. DasGupta, "Molecular Differences Between Type A Botulinum Neurotoxin and Its Toxoid," Toxicon, 27:403 (1989).
H. Towbin et al., "Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications," Proc. Nat'l Acad. Sci. USA, 76:4350 (1979).
K. Weber and M. Osborn, "Proteins and Sodium Dodecyl Sulfate: Molecular Weight Determination on Polyacrylamide Gels and Related Procedures," in The Proteins, 3d Edition (H. Neurath & R. L. Hill, eds), pp. 179-223, (Academic Press, NY, 1975).
S. B. Carroll and A. Laughon, "Production and Purification of Polyclonal Antibodies to the Foreign Segment of .beta.-galactosidase Fusion Proteins," in DNA Cloning: A Practical Approach, vol. III, (D. Glover, ed.), pp. 89-111, IRL Press, Oxford, (1987).
B. S. Thalley and S. B. Carroll, "Rattlesnake and Scorpion Antivenoms From The Egg Yolks of Immunized Hens," Bio/Technology, 8:934-938 (1990).
I. Ohishi et al., "Oral Toxicities of Clostridium botulinum Toxins in Response to Molecular Size," Infect. Immun., 16:106 (1977).
B. W. Wren et al., "Antigenic Cross-Reactivity and Functional Inhibition by Antibodies to Clostridium difficile Toxin A, Streptococcus mutans Glucan-Binding Protein, and a Synthetic Peptide," Infect. Immun., 59:3151-3155 (1991).
M. Ehrich et al., "Production of Clostridium difficile Antitoxin," Infect. Immun. 28:1041-1043 (1980).
Z. A. McGee et al., "Local Induction of Tumor Necrosis Factor as a Molecular Mechanism of Mucosal Damage by Gonococci," Microb. Path. 12:333-341 (1992).
R. Fekety, "Animal Models of Antibiotic-Induced Colitis," in O. Zak and M. Sande (eds.), Experimental Models in Antimicrobial Chemotherapy, vol. 2, pp. 61-7

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