Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-01-07
1997-07-01
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
A61K 3170
Patent
active
056438869
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/GB91/01981 filed Nov. 11, 1991.
This invention relates to a method of treating parasites in dogs.
This invention is particularly concerned with the use of certain avermectins and milbemycins described in EP-A-0 421 568 (U.S. Ser. No. 525,094) for the treatment or prophylaxis of endo- and ectoparasitic infestations of dogs.
The compounds used in this invention have parasiticidal properties, for example against nematodes, and are useful for the treatment of helminthiasis.
The term helminthiasis encompasses diseases of animals caused by infestation with parasitic worms such as Strongyles, Ascarids, hookworms, lungworms, filarial worms and whipworms.
The compounds used in this invention are also active against Arthropods. The phylum Arthropoda comprises insects--such as biting flies, lice, bugs, beetles and fleas--and arachnids--such as mites and ticks.
Thus the present invention provides the use of a compound of general formula (I) as defined below for the manufacture of a medicament for the treatment or prophylaxis of endo and ectoparasitic infestations, especially helminthiasis and arthropod or nematode infestations, in dogs.
The present invention also provides a method of treatment or prophylaxis of endo- and ectoparasitic infestations, especially helminthiasis and anthropod or nematode infestations, which comprises administering an effective non-toxic amount of a compound of general formula (I) as defined below to a dog in need thereof.
This invention is particularly concerned with the use of a compound of general formula (I) to combat round worms, hook worms, whipworms and demodectic mange in dogs. As indicated above, the invention also includes prophylatic treatment against parasites, especially against heartworm, by killing the larval stage.
For use according to the invention the compounds of general formula (I) may be formulated for administration with carriers and adjuvants in any convenient way for use in veterinary medicine, by analogy with known anthelmintics.
In suitable formulations the compounds of general formula (I) may be administered to animals orally (as a paste, drench, bolus, capsule or tablet), parenterally, percutaneously, as a food additive (eg granules, pellets or powder), topically (as a cream, wash or spray), or transdermally (as a pour-on).
The compounds of general formula (I) may be formulated as a mixture with each other and/or with other anthelmintics, insecticides, acaricides or other pharmacologically active substances.
Suitably the composition consists of sufficient material to provide a dose of from 0,001 to 100mg of active ingredient per kg of animal body weight per dose, more suitably 0.01 to 10mg/kg per dose.
A composition for use in the invention may suitably contain from 0.1% by weight, preferably from 1.0 to 60% by weight, of the compound of general formula (I) (based on the total weight of the composition), depending on the method of administration.
It will be appreciated that, in some cases, it will be advisable to repeat the dosing of the infected or potentially infected animal with the compound of general formula (I) according to conventional dosage regimes used with anthelmintics:
The compound used in this invention is an avermectin or milbemycin selected from avermectins and milbemycins having the general formula (I): ##STR1## wherein R.sup.1 is hydrogen or optionally protected hydroxy; R.sup.2 is alkoxy, optionally protected hydroxy, oxo or optionally 0-substituted oximino; R.sup.3 is hydrogen, optionally protected hydroxy,or a group 4'-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrosyloxy or .alpha.-L- oleandrosyloxy wherein the terminal hydroxy group is optionally protected; R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are the same or different and each is hydrogen or an organic radical; and R.sup.8 is an optionally substituted amine or imino group such as optionally 0-substituted oxyimino, optionally N-substituted hydrazone, or optionally N-substituted semicarbazone; with the proviso that the compound of formula (I) is not a compound of
REFERENCES:
CA 114:(23) 228634t. 1991.
Ginsburg Paul H.
Kollar Alan L.
Pfizer Inc.
Richardson Peter C.
Weddington Kevin E.
LandOfFree
Avermectins and milbemycins to treat parasitic infestations in d does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Avermectins and milbemycins to treat parasitic infestations in d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avermectins and milbemycins to treat parasitic infestations in d will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-597196