Avermectin ketal derivatives useful as antiparasitic

Details Avermectin ketal derivatives useful as antiparasitic Avermectin ketal derivatives useful as antiparasitic

1990-07-23

1991-12-31

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549264, 549265, A61K 31365, C07D49322

Patent

active

050773089

ABSTRACT:
There are disclosed avermectin aglycone derivatives which incorporate a ketal at position 13. The synthetic ketal analogs are derived from the corresponding ketones which in turn are prepared by chemical modification of naturally occurring avermectins. The compounds are active antiparasitic agents and compositions for that use are disclosed.

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H. Mrozik et al., J. Org. Chem., "Avermectin Aglycons," 47(3), pp. 489-492 (1982).
G. Carter et al., J. Antiobiotics, "LL-F28249 Antibiotic Complex," 41(4), pp. 519-529 (1988).
G. Albers-Schonberg et al., J. Am. Chem. Soc., "Avermectins Structure Determination," 103(14), pp. 4216-4221 (1981).
J. Chabala et al., J. Med. Chem., "Avermectin, a New Broad-Spectrum Antiparasitic Agent," 23(10), 1134-1136 (1980).

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