Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-04-29
1993-07-20
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549264, C07D31500
Patent
active
052294161
ABSTRACT:
Avermectin derivatives are disclosed which incorporate two fluorine atoms at the 4' monosaccharide position, the 4" disaccharide position or the 23 position. Avermectin aglycone derivatives are also disclosed which incorporate two fluorine atoms at position 13 or 23. These difluoro avermectin analogs are derived from corresponding ketones and enones which in turn are prepared by chemical modification of naturally occurring avermectins. These compounds are used as antiparisitic, insecticidal and antihelmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.
REFERENCES:
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4173571 (1979-11-01), Chabala et al.
The Merck Index, Abstract 5133, pp. 825 and 826 of the Eleventh Edition, 1991.
Fisher Michael H.
Meinke Peter T.
Mrozik Helmut
Ayler Sylvia A.
Cintins Marianne M.
Daniel Mark R.
DiPrima Joseph F.
Hydorn Michael B.
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