Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

1987-03-16

1989-02-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, 549264, 71 88, A61K 3170, C07H 1704, C07D31306

Patent

active

048065277

ABSTRACT:
There are disclosed derivatives of avermectin compounds with a .DELTA.26,27-alkyl chain of 4, 5 or 6 members at the 25-position. The compounds are prepared from the known .DELTA.26,27-compounds by the appropriate synthetic procedures at the 5-, 8-, 9-, 13- , 22- and 23-positions. The compounds are potent antiparasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4173571 (1979-11-01), Chabala et al.
patent: 4203979 (1980-05-01), Fisher et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.

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