Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

1989-06-02

1991-10-15

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, 549265, A61K 3170, A61K 3135, C07H 1704, C07D30500

Patent

active

050574990

ABSTRACT:
There are disclosed novel avermectin derivatives wherein the outer oleandrose ring of avermectin or avermectin monosaccharide is homologated by addition of diazomethane to 4"- or 4'-oxo-avermectin to afford the perhydrooxepine derivatives. The homologated avermectins can then be further derivatized to afford additional novel avermectins. The new compounds are potent antiparasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

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Fisher et al., Nat. Prod. Rep., 3, pp. 87-121 (1986).
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