Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

1989-07-31

1991-06-11

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, A61K 3170, C07H 1704

Patent

active

050232410

ABSTRACT:
Novel avermectin derivatives are disclosed, wherein the 4"-hydroxy group is replaced by a substituted acylamino or benzoylamino group. These avermectin derivatives can be further derivatized at the 5- and 23-positions as ketoximes or O-substituted ketoximes. The 4"-substituted avermectin derivatives are prepared by the acylation of the known 4"-aminoavermectins with acylating reagents. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

REFERENCES:
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4427663 (1984-01-01), Mrozik
patent: 4806527 (1989-02-01), Christensen et al.
patent: 4831016 (1989-05-01), Mrozik et al.
Chen et al., Abstr. Pap Am. Chem. Soc. (186 Meet, MBTD 28, 1983).
Schulman et al (I), J. Antibiotic 38, pp. 1494-1498 (1985).
Schulman et al. (II), Antimicrobial Agents and Chemotherapy 31, pp. 744-747 (1987).
Fisher et al., Macrolide Antibiotics, Omura (Ed.) Academic Press, New York, pp. 553-606 (1984).
Davies et al., Nat. Prod. Rep. 3, pp. 87-121 (1986).

Affiliated with

Also associated with

Rating

Avermectin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Avermectin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avermectin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-782665