Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

2007-07-31

2007-07-31

Peselev, Elli (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007100

Reexamination Certificate

active

10997869

ABSTRACT:
A compound represented by the general formula (I) or a salt thereof:whereinrepresents —CH═CH—, —CH2—CH2— or the like,between R1and the carbon atom at 4′-position represents a single bond or a double bond,between R2and the carbon atom at 5-position represents a single bond or a double bond, and for example, 1) whenrepresents —CH═CH— or —CH2—CH2—, andbetween R1and the carbon atom at 4′-position represents a double bond, R1represents ═C(R11)(R12) (wherein R11represents a lower alkyl group or the like and R12represents a hydrogen atom or the like) or the like, and R2represents a hydroxyl group or the like, or R2may be combined together with the carbon atom at 5-position to form a carbonyl group, and 2) whenrepresents —CH═CH— or —CH2—CH2—, andbetween R1and the carbon atom at 4′-position represents a single bond, R1represents —OCH(R1a)(R1b) (wherein R1arepresents a lower alkyl or the like and R1brepresents a hydrogen atom or the like) or the like, and R2represents a hydroxyl group or the like.

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English Language Abstract of JP 3-254678 (provided by esp@cenet).
English Language Abstract of JP 3-74397 (provided by esp@cenet).
English Language Abstract corresponding to JP 6-33273 (provided by esp@cenet).
Chabala, J.C. et al., “Ivermectin, a New Broad-Spectrum Antiparasitic Agent,” J. Med. Chem., 1980, 23, pp. 1134-1136.
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