Avermectin derivatives

Details Avermectin derivatives Avermectin derivatives

1989-06-02

1991-07-09

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 71, A61K 3170, C07H 1704

Patent

active

050306227

ABSTRACT:
There are disclosed novel avermectin derivatives wherein the outer oleandrose ring of avermectin or avermectin monosaccharide is homologated by addition of diazomethane to 4"- or 4'-oxo-avermectin to afford the oleandrose 4"- or 4'-spiro-epoxide. The homologated avermectins can then be further derivatized to afford additional novel avermectins. The new compounds are potent antiparasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

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Davies et al., Nat. Prod. Rep. 3, pp. 87-121 (1986).
Streitwieser, Jr. et al., Introduction to Organic Chemistry, Second Edition, p. 804 (1981).

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