Avermectin compounds with a 6,5-spiroketal ring system

Details Avermectin compounds with a 6,5-spiroketal ring system Avermectin compounds with a 6,5-spiroketal ring system

1991-06-17

1993-01-05

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, A61K 3170, A61K 31365, C07D31500

Patent

active

051770636

ABSTRACT:
Avermectin analogs are disclosed wherein the 6,6-spiroketal ring system has been reduced in size to a 6,5-spiroketal ring system by the deletion of the 25-position carbon atom and the 25-alkyl substituent. This is accomplished by opening the outer spiroketal ring with the elimination of ring carbon atoms 23, 24 and 25 and the alkyl substituent at the 25-position and incorporation a new component, reclosing the spiroketal to a 5-membered ring with new substituents at the 24-position. The compounds are used as anti-parasitic insecticidal and anti-helmintic agents in humans and animals and compositions containing such compounds as the active ingredient thereof are also disclosed.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4895837 (1990-01-01), Mrozik et al.
patent: 4906619 (1990-03-01), Eskola et al.
T. L. Shih, et al. Tetra Letters vol. 31, No. 25 pp. 3525-3528.
T. L. Shih, et al. Tetra. Letters vol. 31, No. 25 pp. 3529-3532 (1990).

Affiliated with

Also associated with

Rating

Avermectin compounds with a 6,5-spiroketal ring system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Avermectin compounds with a 6,5-spiroketal ring system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Avermectin compounds with a 6,5-spiroketal ring system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2390646