Avermectin and milbemycin phosphate esters, pharmaceutical compo

Details Avermectin and milbemycin phosphate esters, pharmaceutical compo Avermectin and milbemycin phosphate esters, pharmaceutical compo

1983-01-28

1984-09-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

424279, 536 71, 549220, 549264, A61K 3170, C07H 1708, C07D49322

Patent

active

044696825

ABSTRACT:
There are disclosed novel avermectin and milbemycin compounds wherein the various hydroxy groups are substituted with a phosphate ester group. The phosphate esters are prepared by reacting an avermectin or milbemycin compound with one or more unprotected hydroxy groups with a disubstituted halo phosphate. The avermectin and milbemycin phosphate esters have increased water solubility when compared with the parent compounds. The phosphate ester compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

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