Avermectin aglycon synthase genes

Details Avermectin aglycon synthase genes Avermectin aglycon synthase genes

2008-05-13

2008-05-13

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

C435S252300, C435S252350, C435S320100, C536S023200

Reexamination Certificate

active

07371548

ABSTRACT:
The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the biosynthesis of a polyketide compound, or its mutants having avermectin aglycon synthase activity, particularly functional modules and submodules in the DNA sequence derived fromStreptomyces avermitilis, a polypeptide or mutants thereof encoded by the DNA or the mutants, a vector containing the DNA or the mutants, a host cell transformed with the DNA, the mutants thereof, or the vector, and a method for producing avermectin.

REFERENCES:
patent: 5252474 (1993-10-01), Gewain et al.
patent: 391594 (1990-10-01), None
patent: 0445460 (1991-09-01), None
patent: 791655 (1997-08-01), None
patent: 791656 (1997-08-01), None
patent: WO 00/01827 (2000-01-01), None
patent: WO 01/09155 (2001-02-01), None
Bevitt et al. “6-deoxyerythronolide-B synthase 2 fromSaccharopolyspora erythraea” XP-001005944 Eur. J. Biochem. 204:39-49 (1992).
Cortes et al. “An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase ofSaccharopolyspora erythraea” XP-002035889 Nature 348:176-178 (1990).
Database Accession No. AB032367 XP-0022769974 (1999).
Database Accession No. L09654 XP-002276973 (1993).
Database Accession No. AF079138 XP-002276971 (1998).
Database Accession No. AF082100 XP-002276972 ((1998).
Donadio et al. “Modular organization of genes required for complex polyketide biosynthesis” XP-002035890 Science 252:675-679 (1991).
Ikeda et al. “Cloning of the gene encoding avermectin B 5-O-methyltransferase in avermectin-producingStreptomyces avermitilis” Gene 206:175-180 (1998).
Ikeda et al. “Avermectin Biosynthesis” XP002941702 Chem. Rev. 97:2591-2609 (1997).
Ikeda et al. “Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin inStreptornyces avernitilis”, PNAS 96:9509-9514 (1999).
Ikeda “Genetic analysis of biosynthesis of polyketide anthelmintic macrolide avermectin inStreptomyces avermitilis” XP-001180664 Actinomycetol. 13:94-112 (1999).
Ikeda et al. “Control of avermectin biosynthesis inStreptomyces avermitilis” XP-009029162 J. Antibiotics 48:549-562 (1995).
Kue et al. “A gene cluster for macrolide anti-biotic biosynthesis inStreptomyces venezuelac:Architecture of metabolic diversity” PNAS 95:12111-12116 (1998).
MacNeil et al. “Correlation of the avermectin polyketide synthase genes to the avermectin structure”, Ann. Acad. Sci. 721:123-132 (1994).
MacNeil et al. “Complex organization of theStreptomyces avernitilisgenes encoding the avermectin polyketide synthase” Gene 115:119-125 (1992).
MacNeil et al. “Deletion analysis of the avermectin biosynthetic genes ofStreptomyces avermitilisby gene cluster displacement” XP009008304 J. Bacteriol. 175:2552-2563 (1993).
Marsden et al. “Engineering broader specific- ity into an antibiotic-producing polyketide synthase” Sci. 279:199-202 (1998).
Motamedi et al. “The biosynthetic gene cluster for the macrolactone ring of the immunosuppressant FK506” XP-000906738 Eur. J. Biochem. 256:528-534 (1998).
Omura et al. “Selective production of specific components of avermectins inSterptomyces avermitilis” XP-009029161 J. Antibiotics 44:560-563 (1991).
Pang et al. “Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain ofStreptomyces avermitilis” XP-009029187 J. Antibiotics 48:59-66 (1995).
Swan et al. “Characterisation of aStreptomyces antibioticusgene encoding a type I polyketide synthase which has an unusual coding sequence” XP-002087278 Mol. Gen. Genet. 242:358-362 (1994).
European Search Report for European Appln. No. 00905297.8 dated May 14, 2004.
Search Report dated May 14, 2004 for European Appln. No. 00905297.8.
Supplementary Partial European Search Report dated Apr. 15, 2003.

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