Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition

Details Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition Avermectin 8,9-cyclopropyl compounds, pharmaceutical composition

1985-04-08

1986-04-08

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, A61K 3171, C07H 1708

Patent

active

045813450

ABSTRACT:
There are disclosed novel avermectin 8,9-cyclopropyl compounds (also referred to as 8,9-dihydro-8,9-methano avermectin compounds). The 8,9-cyclopropyl compounds are prepared by treating an avermectin compound with an iodohalomethane compound in the presence of an activated form of zinc. The avermectin 8,9-cyclopropyl compounds have utility as anti-parasitic agents and compositions for that use are also disclosed. The compounds are also highly potent insecticides against agricultural pests.

REFERENCES:
patent: 4412991 (1983-11-01), Ormond
patent: 4427663 (1984-01-01), Mrozik
patent: 4459290 (1984-07-01), Kirst et al.

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