Avarone and its pharmaceutical compositions and use as an antivi

Details Avarone and its pharmaceutical compositions and use as an antivi Avarone and its pharmaceutical compositions and use as an antivi

1989-12-29

1993-01-19

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514965, 514966, A61K 3112

Patent

active

051807483

ABSTRACT:
The antitumor and antiviral compound avarone, a process for its production, pharmaceutical compositions containing said compound, and a method of combating susceptible viruses and tumors therewith, are disclosed.

REFERENCES:
Minale et al., Tetrahedron Lett., No. 38, 3401-3404 (1974) by Pergamon Press.
Muller et al., J. Bacteriol, 145, 548-558.
Comp. Biochem. Physiol. 71B, pp. 281-283 (1982).
Experientia 38, p. 896 (1982).
Chemical Abstracts 97, p. 462, item 97:21000t (1982).
Kurelec, B., et al., "Antimutagenic activity of the novel antileukemic agents, avarone and avarol", Mutation Research, 144 (1985) pp. 63-66.
Muller, W. E. G., "Potent Antileukemic Activity of the Novel Cytostatic Agent Avarone and its Analogues in Vitro and in Vivo", Cancer Research 45 (1985) pp. 1-5.
Muller, W. E. G., et al., "Avarol, a Cytostatically Active Compound from the Marine Sponge Dysidea avara", Comp. Biochem, Physiol. 80C No. 1, (Jan. 31, 1985) pp. 47-52.
Muller, W. E. G., et al., J. Antibiotics 37, 239 (1984).
Cariello, L., et al., "Developmental Aberrations in Sea-Urchin Eggs Induced by Avarol and Two Cogeners, the Main Sesquitterpenoid Hydroquinones from the Marine Sponge, Dysidea avara", Comp. Biochem. Physiol., 65C, pp. 37-41 (1980).

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