Avarol, process for its production, pharmaceutical compositions

Details Avarol, process for its production, pharmaceutical compositions Avarol, process for its production, pharmaceutical compositions

1986-01-17

1990-08-07

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

A61K 31045

Patent

active

049468693

ABSTRACT:
The antiviral compond avarol, a process for its production, pharmaceutical compositions containing said compound, and a method of combating viruses therewith, are disclosed.

REFERENCES:
Comp. Biochem. Physiol. 71B, pp. 281-283 (1982).
Tetrahedon Letters 38, pp. 3401-3404 (1974) by Pergamon Press.
Experientia 38, p. 896 (1982).
Chemical Abstracts 97, p. 462, item 91:21000t (1982).
Kurelec, B., et al., "Antimutagenic activity of the novel antileukemic agents, avarone and avarol", Mutation Research, 144 (1985) pp. 63-66.
Muller, W. E. G., "Potent Antileukemic Activity of the Novel Cytostatic Agent Avarone and its Analogues in Vitro and in Vivo", Cancer Research 45 (1985) pp. 1-5.
Muller, W. E. G., et al., "Avarol, a Cytostatically Active Compound from the Marine Sponge Dysidea Avara", Comp. Biochem, Physiol. 80C No. 1, (Jan. 31, 1985) pp. 47-52.
Muller, W. E. G., et al., J. Antibiotics 37, 239 (1984).
Cariello, L., et al., "Developmental Aberrations in Sea-Urchin Eggs Induced by Avarol and Two Cogeners, the Main Sesquitterpenoid Hydroquinones from the Marine Sponge, Dysidea Avara", Comp. Biochem, Physiol., 65C, pp. 37-41 (1980).

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