Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – C-o-group doai
Patent
1989-12-29
1992-01-21
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
C-o-group doai
A61K 31045
Patent
active
050828657
ABSTRACT:
The antitumor compound avarol, a process for its production, pharmaceutical compositions containing said compound, and a method of combating tumors therewith, are disclosed.
REFERENCES:
Comp. Biochem. Physiol. 71B, pp. 281-283 (1982).
Tetrahedron Letters 38, pp. 3401-3404 (1974) by Pergamon Press.
Experientia 38, p. 896 (1982).
Chemical Abstracts 97, p. 462, item 97:21000t (1982).
Kurelec, B. et al., "Antimutagenic Activity of the Novel Antileukemic Agents, Avarone and Avarol", Mutation Research, 144 (1985), pp. 63-66.
Muller, W. E. G., "Potent Antileukemic Activity of the Novel Cytostatic Agent Avarone and its Analogues in Vitro and in Vivo", Cancer Research 45 (1985), pp. 1-5.
Muller, W. E. G. et al., "Avarol, A Cytostatically Active Compound from the Marine Sponge Dysidea avara", Comp. Biochem, Physiol. 80C, No. 1, (Jan. 31, 1985), pp. 47-52.
Muller, W. E. G. et al., J. Antibiotics 37, 239 (1984).
Cariello, L. et al., "Developmental Aberrations in Sea-Urchin Eggs Induced by Avarol and Two Cogeners, the Main Sesquitterpenoid Hydroquinones from the Marine Sponge, Dysidea avara", Comp. Biochem, Physiol., 65C, pp. 37-41 (1980).
Eich Eckart
Muller Werner E. G.
Zahn Rudolf K.
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