Auxiliary genes and proteins of methicillin resistant bacteria a

Details Auxiliary genes and proteins of methicillin resistant bacteria a Auxiliary genes and proteins of methicillin resistant bacteria a

1996-07-10

2000-10-24

Navarro, Albert

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

4352534, 4353201, 536 231, 536 237, C12N 120, C12N 1500, C07H 2102, C07H 2104

Patent

active

061365874

ABSTRACT:
The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus, to identify the characteristics of such bacteria and develop drugs that can reverse, inhibit, or reduce bacterial resistance to beta lactam antibiotics, e.g., methicillin. The invention particularly relates to identification of a novel mutant strain of methicillin resistant S. aureus that manifests a unique phenotype. Accordingly, the invention provides for methods of treatment and corresponding pharmaceutical compositions for treating bacterial, particularly staphylococcal, infections.

REFERENCES:
patent: 4431739 (1984-02-01), Riggs
Wu et al. (1996) Microb. Drug Resist. 2:277-85.
Berger-Bachi (1994) Trends in Microbiol. 2:389-92.
De Lencastre et al. (1994) Antimicrob. Agent. Chemother. 38:2590-8
De Lencastre et al. (1994) Eur. J. Clin. Microbiol. Infect. Dis. 13:64-73.
De Lencastre et al. (1994) J. Antimicrob. Chemother. 33:7-24.
Ornelas-Soares et al. (1994) J. Biol. Chem. 269:27246-50.
De Jonge et al. (1993) Animicrob. Agents Chemother. 37:342-6.
De Jonge et al. (1993) J. Bacteriol. 1751:2779-82.
Gustafson (1993) Abst. 93rd Gen. Meet. Am. Soc. Microbiol., A-97, p. 18.
Henze et al. (1993) J. Bacteriol. 175:1612-20.
Ornelas-Soares et al. (1993) J. Biol. Chem. 268:26268-72.
Berger-Bachi et al. (1992) Antimicrob. Agents Chemotherapy 36:1367-73.
De Jonge et al. (1992) J. Biol. Chem. 267:11248-54.
De Jonge et al. (1992) J. Biol. Chem. 267:11255-9.
Oshida et al. (1992) J. Bacteriol. 174:4952-9.
Wenzel et al. (1992) Am. J. Med. 91(Supp. 3B):221-7.
Blumberg et al. (1991) J. Inf. Disease 63:1279-85.
De Jonge et al. (1991) J. Bacteriol. 173:1105-10.
De Lencastre et al. (1991) Animicrob. Agents Chemother. 35:632-9.
Maidhof et al. (1991) J. Bacteriol. 173:3507-13.
Tomasz et al. (1991) Antimicrobial Agents and Chemotherapy 35:124-9.
Matthews et al. (1990) Antimicrobial Agents and Chemotherapy 34:1777-9.
Matthews et al. (1990) In: Molecular Biology of the Staphylococci, Novick and Skurray, Eds., VCH Publishers; New York, pp. 69-83.
Tomasz, (1990) In: Molecular Biology of the Staphylococci, Novick and Skurray, Eds., VHC Publishers: New York, pp. 565-583.
Murakami et al. (1989) J. Bacteriol. 171:874-9.
Leclercg et al. (1988) New Eng. J. Med. 319:157-61.
Hartman et al. (1986) Animicrob. Agents Chemother. 30:29:85-92.
Tonin et al. (1986) Animicrob. Agents Chemother. 30:577-83.
Beck et al. (1985) J. Bacteriol. 165:373-8.
Berger-Bachi (1983) J. Bacteriol. 154:479-87.
Basheer et al. (Nucleic Acids Research vol. 19 No. 18 pp. 4921-4924), 1991.
Ornelas-Soares et al. (J. of Biol. Chem. vol. 269 No. 44 pp. 27246-27250), Nov. 4, 1994.
Oshida et al. (J. of Bacteriology vol. 174 No. 15 pp. 4952-4959), Aug. 1992.
Berger-Bachi et al. Antimicrobial Agents & Chemo. vol. 36 No. 7 pp. 1367-1373, Jul. 1992.
Tanaka et al. (Science vol. 242 pp. 1040-1042), Nov. 18, 1988.

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