Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1996-07-10
2000-01-11
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
4352521, 4353201, 536 237, C12N 121, C12N 1531, C12N 1563
Patent
active
060135077
ABSTRACT:
The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus, to identify the characteristics of such bacteria and develop drugs that can reverse, inhibit, or reduce bacterial resistance to beta lactam antibiotics, e.g., methicillin. The invention particularly relates to identification of a novel mutant strain of methicillin resistant S. aureus that manifests a unique phenotype. Accordingly, the invention provides for methods of treatment and corresponding pharmaceutical compositions for treating bacterial, particularly staphylococcal, infections.
REFERENCES:
Berger-Bachi et al. (1992) Mapping and characterization of multiple chromosomal factors involved in methicillin resistance in Staphylococcus aureus. Antimicrobial Agents Chemotherapy 36:1367-1373, Jul. 1992.
Ornelas-Soares et al. (1994) Reduced methicillin resistance in a new Staphylococcus aureus transposon mutant that incorporates muramyl dipeptides into the cell wall peptidoglycan. J. Biol. Chem. 268:27246-27250, Nov. 1994.
De Lancastre et al. (1994) Molecular aspects of methicillin resistance in Staphylococcus aureus. J. Antimicrobial Chemotherapy 33:7-24.
Berger-Bachi et al. (1989) FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: Molecular cloning and characterization. Mol. Gen. Gen. 219:263-269.
Sambrook et al. Molecular Cloning, A Laboratory Manual (2nd Ed.) Cold Spring Harbor Laboratory Press, 1989, pp. 9.47-9.62.
De Lencastre et al. (1994) Antimicrob. Agent. Chemother. 38:2590-8.
De Lencastre et al. (1994) Eur. J. Clin. Microbiol. Infect. Dis. 13:64-73.
De Jonge et al. (1993) Animicrob. Agents Chemother. 37:342-6.
De Jonge et al. (1993) J. Bacteriol. 1751:2779-82.
Gustafson et al. (1993) In: Abstracts of the 93rd General Meeting of the American Society for Microbiology, Abs. A-97, p. 18.
Ornelas-Soares et al. (1993) J. Biol. Chem. 268:26268-72.
De Jonge et al. (1992) J. Biol. Chem. 267:11248-54.
De Jonge et al. (1992) J. Biol. Chem. 267:11255-9.
De Jonge et al. (1991) J. Bacteriol. 173:1105-10.
De Lencastre et al. (1991) Animicrob. Agents Chemother. 35:632-9.
Maidhof et al. (1991) J. Bacteriol. 173:3507-13.
Tomasz et al. (1991) Antimicrobial Agents and Chemotherapy 35:124-9.
Matthews et al. (1990) Antimicrobial Agents and Chemotherapy 34:1777-9.
Matthews et al. (1990) In: Molecular Biology of the Staphylococci, Novick and Skurray, Eds., VCH Publishers; New York, pp. 69-83.
Tomasz, (1990) In: Molecular Biology of the Staphylococci, Novick and Skurray, Eds., VHC Publishers: New York, pp. 565-583.
Murakami et al. (1989) J. Bacteriol. 171:874-9.
Tonin et al. (1986) Animicrob. Agents Chemother. 30:577-83.
Beck et al. (1985) J. Bacteriol. 165:373-8.
Berger-Bachi (1983) J. Bacteriol. 154:479-87.
De Lencastre Herminia
Tomasz Alexander
Elliott George C.
Schwartzman Robert
The Rockefeller University
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