Auxiliary gene and protein of methicillin resistant bacteria and

Details Auxiliary gene and protein of methicillin resistant bacteria and Auxiliary gene and protein of methicillin resistant bacteria and

1996-07-10

1999-11-16

Carlson, Karen Cochrane

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

536 237, 435883, C12N 1100, C07H 1700

Patent

active

059856432

ABSTRACT:
The present invention is directed to the identification of mutant strains of methicillin resistant bacteria, in particular methicillin resistant Staphylococcus aureus, to identify the characteristics of such bacteria and develop drugs that can reverse, inhibit, or reduce bacterial resistance to beta lactam antibiotics, e.g., methicillin. The invention particularly relates to identification of a novel mutant strain of methicillin resistant S. aureus that manifests a unique phenotype, having a block in cell wall synthesis at or close to the branch point in hexose metabolism involved in the synthesis of cell wall components. Accordingly, the invention provides for methods of treatment and corresponding pharmaceutical compositions for treating bacterial, particularly staphylococcal, infections.

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