Autoradiographic digital imager

Radiant energy – Invisible radiant energy responsive electric signalling – Semiconductor system

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H01L 31115

Patent

active

054752256

ABSTRACT:
A real-time autoradiographic digital imager for accurately quantifying the spatial distribution of radio pharmaceuticals in tissue samples having a sensor for converting the energy of radionuclide particles to an electrical signal, external off-chip electronics for sensor timing and signal conditioning, a computer for data processing and image display and a high voltage supply to support the sensor operations. The sensor has a scintillator or phosphor for converting particle energy to lower energy photons, a microchannel plate high-resolution-amplifier for amplifying the photon signal, and a readout chip structure for converting the photon signal to an electrical signal. The readout chip structure consists of a detector array for converting the photons to an electrical charge, and a readout array for storing the data and providing the data, with low noise, to the output portion of the external electronics. The detector array and readout array are electrically connected by conducting bumps; the detector array is composed of detectors, and the readout array is composed of unit cells. Each unit cell is associated with a single detector in the detector array and contains readout electronics which produce data in response to radiation from tissue samples. Both the readout and external electronics provide the data in digitized form, in real-time, to a processing computer and CRT display.

REFERENCES:
patent: 4067104 (1978-01-01), Tracy
patent: 4931647 (1990-06-01), Hiruma et al.
patent: 5099128 (1992-03-01), Stettner
patent: 5140162 (1992-08-01), Stettner
Koh-ichi Mochiki, Ken-ichi Hasegawa and Shuji Namatame, "Amorphous Silicon Position-Sensitive Detector." Nuclear Instruments and Methods in Physics Research, vol. A273 (1988) pp. 640-644 Copyright .COPYRGT. Elsevier Science Publishers B.V.

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