Autonomous parvovirus gene delivery vehicles and expression vect

Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses

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4353201, 435 691, 435 703, 435 911, 435 9121, 435 913, 435 9131, 435 9132, 4352351, 424 932, 424405, 536 231, 536 237, 536 241, 536 245, C12N 1563, C12N 1586, C12N 701, C12N 1564

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055852548

ABSTRACT:
The present invention relates to novel recombinant autonomous parvovirus vectors, novel recombinant virus particles, and novel gene delivery vehicles that can be used to selectively target heterologous nucleic acid sequences to desired cell types and to selectively express such sequences in such desired cell types. Recombinant autonomous parvovirus gene delivery vehicles are particularly advantageous for transient gene therapy, and are especially well-suited to treat diseases in which there is rapid cell growth, such as cancer. Also included is the use of recombinant vectors of the present invention to produce RNA and protein products in cell culture.

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