Radiant energy – Ionic separation or analysis – Methods
Reexamination Certificate
2011-06-14
2011-06-14
Kim, Robert (Department: 2881)
Radiant energy
Ionic separation or analysis
Methods
C250S281000, C250S283000, C250S288000, C250S286000
Reexamination Certificate
active
07960690
ABSTRACT:
An automatic gain control (AGC) technique and apparatus is introduced herein for any temporally non-uniform ion beam, such as, for example, an ion beam produced by a MALDI ion source so as to minimize space charge effects. The disclosed configurations and techniques can be achieved by using an ion optical gating element and applying a desired signal waveform (e.g., a square wave) having a predetermined duty cycle. The applied voltage amplitude of such a signal can be configured to switch between a voltage which fully transmits the ions, and a voltage which does not transmit any ions. The frequency is chosen to result in a period which is significantly lower than the smallest non-uniformity period. Techniques of the present invention can also be extended to methods of AGC which can use a single ion injection event from the ion source to avoid variations in ion numbers from an unstable ion source.
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Page et al. “Automatic Gain Control in Mass Spectrometry Using a Jet Disrupter Electrode in an Electrodynamic Ion Funnel” Journal of the American Society for Mass Spectrometry, 2005, 16, pp. 244-253.
Kovtoun Viatcheslav V.
Schwartz Jae C.
Kim Robert
Purinton Brooke
Staggs Michael C.
Thermo Finnigan LLC
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