Image analysis – Applications – Biomedical applications
Patent
1996-06-13
2000-02-01
Johns, Andrew W.
Image analysis
Applications
Biomedical applications
382257, G06K 900
Patent
active
060212136
ABSTRACT:
An automatic contextual segmentation method which can be used to identify features in QCT images of femora, tibiae and vertebrae. The principal advantages of this automatic approach over traditional techniques such as histomorphometry are, 1) the algorithms can be implemented in a fast, uniform, non-subjective manner across many images allowing unbiased comparisons of therapeutic efficacy, 2) much larger volumes in the region of interest can be analyzed, and 3) QCT can be used longitudinally. Two automatic contextual segmentation algorithms relate to a cortical bone algorithm (CBA) and a whole bone algorithm (WBA). These methods include a preprocessing step, a threshold selection step, a segmentation step satisfying logical constraints, a pixel wise label image updating step, and a feature extraction step; with the WBA including whole bone segmentation, cortical segmentation, spine segmentation, and centrum segmentation. The algorithms are constructed to provide successful segmentations for known classes of bones with known topological constraints.
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Helterbrand Jeffrey Donald
Higgs, Jr. Richard Earl
Iversen Philip Wayne
Eli Lilly and Company
Johns Andrew W.
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