Automated scanning of microscope slides

Optical: systems and elements – Compound lens system – Microscope

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Details

359368, 356244, G02B 2126

Patent

active

060494212

ABSTRACT:
A system is provided for the automated imaging of a succession of microscope slides (S). The slides are mounted in carriers and loaded into cassettes. Slide carriers from a first cassette in a slide loader (2) are ejected from the cassette into a loading station and thence moved by an actuator onto a stage beneath a microscope objective (6) which images a sub-area of a circular sample area on the slide onto an imaging sensor (10) whence images are digitized and stored. The stage (4) is conjointly rotated by a motor (22) as a carrier (24) for the stage is moved linearly, so as to execute a spiral scan of sub-areas of the sample area which sub-areas are successively imaged using a strobe lamp (12) to illuminate the sample area at intervals during the scan determined by signals from an encoder (25). A preliminary scan, which may be in an opposite direction along the spiral, may be used to obtain, for a focus actuator (18), focusing data used during the scan. As a following slide carrier is loaded onto the stage for scanning, the previous slide carrier is ejected into a chute from which an actuator inserts it into a further cassette in the same orientation in which it left the first cassette.

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patent: 5367401 (1994-11-01), Saulietis
patent: 5386318 (1995-01-01), Kuhnert et al.
patent: 5446584 (1995-08-01), Bacchi et al.
patent: 5473706 (1995-12-01), Bacus et al.

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