Automated peptide synthesizer

Details Automated peptide synthesizer Automated peptide synthesizer

1993-10-05

1994-11-08

Redding, David A.

Chemical apparatus and process disinfecting, deodorizing, preser

Chemical reactor

Organic polymerization

422 62, 422 681, 422116, 422125, 422134, 436 89, 935 87, 935 88, B01J 802, C07C10352

Patent

active

053624475

ABSTRACT:
The present invention is directed to an automated peptide synthesizer equipped with recovery lines including an acyl component recovery line for recovering unreacted acyl components to allow the reuse of the acyl components, and a solvent recovery line for recovering and distilling a reaction solvent and passing it through a purification column to allow the reuse of the reaction solvent. Both recovery lines are installed on the flow pathway from one or more reaction chambers or columns to a waste liquid reservoir of the automated peptide synthesizer. By recovering expensive acyl components and solvents, running cost in peptide synthesis can be reduced to mitigate economic burden, and the amount of waste leading to environmental destruction can be reduced.

REFERENCES:
patent: 4362699 (1982-12-01), Verlander et al.
patent: 4748002 (1988-05-01), Neimark et al.
Merrifield, Solid Phase Synthesis, Science 232, pp. 341-347, Apr. 18, 1986.

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