Automated on-line evaporation light scattering detection to quan

Details Automated on-line evaporation light scattering detection to quan Automated on-line evaporation light scattering detection to quan

1998-12-22

2000-06-20

Therkorn, Ernest G.

Liquid purification or separation

Processes

Chromatography

6561982, 73 6152, 436161, B01D 1508

Patent

active

06077438&

ABSTRACT:
Single pass methods and systems for measuring the total masses of individual compounds present in fluid samples in real time, and particularly for fluid samples prepared in microtiter plate format are provided. Individual compounds are isolated by fluid separation column (14). Portions of the individual compounds isolated by column (14) are analyzed by mass spectrometer (16), which determines their concentration on the basis of their molecular weights, and an evaporative light scattering detector (24), (which determines the total masses of each of the isolated compounds passing therethrough). Total collected masses of the individual compounds are calculated by determining the amount and portion of the isolated compounds diverted into evaporative light scattering detector (24) during a period of fraction collection.

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Roda, Aldo et al., High-Performance Liquid Chromatographic-Electrospray Mass Spectrometric Analysis of Bile Acids in Biological Fluids, Journal of Chromatography B, 665 (1995) pp. 281-294.
Garr, PhD, Cheryl et al., The Use of Evaporative Light Scattering in Quality Control of Combinatorial Libraries, MDS Panlabs, Inc., Apr. 28-29, 1997, pp. 1-18.

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