Chemistry: analytical and immunological testing – Biological cellular material tested
Patent
1996-11-01
1998-10-06
Pyon, Harold Y.
Chemistry: analytical and immunological testing
Biological cellular material tested
422 82, 436172, 435 2, 356 39, 356336, 356337, G01N 3348
Patent
active
058175199
ABSTRACT:
The present invention provides a highly sensitive and accurate method and system for the discrimination and quantification of platelets in a whole blood sample using automated hematology instruments. The method and system of the invention provide the accurate measurements of platelet dry mass and platelet component concentration in both normal blood samples and in abnormal blood samples, such as those from thrombocytopenic patients. The determination of platelet dry mass and platelet component concentration can serve to assess the activation state of platelets since activated platelets possess measurably lower component concentrations and refractive indices than do unactivated platelets. The method and system of the invention also allows the clinician or skilled practitioner to determine the age of a blood sample on the basis of the measured parameter of platelet component concentration.
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Chapman Evelyn Sabrinah
Colella Gregory M.
Hetherington Edward J.
Paseltiner Lynn
Zelmanovic David
Bayer Corporation
Pyon Harold Y.
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