Automated macromolecular crystal detection system and method

Image analysis – Applications – Manufacturing or product inspection

Reexamination Certificate

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C382S199000, C378S073000, C702S019000

Reexamination Certificate

active

10452668

ABSTRACT:
An automated macromolecular method and system for detecting crystals in two-dimensional images, such as light microscopy images obtained from an array of crystallization screens. Edges are detected from the images by identifying local maxima of a phase congruency-based function associated with each image. The detected edges are segmented into discrete line segments, which are subsequently geometrically evaluated with respect to each other to identify any crystal-like qualities such as, for example, parallel lines, facing each other, similarity in length, and relative proximity. And from the evaluation a determination is made as to whether crystals are present in each image.

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