Automated in-process ratio mass spectrometry

Details Automated in-process ratio mass spectrometry Automated in-process ratio mass spectrometry

2005-12-13

2005-12-13

Anderson, Bruce (Department: 2881)

Radiant energy

Ionic separation or analysis

Methods

C250S281000, C250S288000

Reexamination Certificate

active

06974951

ABSTRACT:
A method and associated apparatus for in-process automated analysis employing a mass spectrometry ratio measurements is disclosed. It involves elemental and speciation threshold measurement that is optimized for quality assurance at and is capable of functioning at and near quantitative instrumental detection limits. The system is automated and may be employed in an unattended operation for identification and quantification of elemental or specie contaminants. In a preferred aspect of the method, a sample is subjected to equilibration with at least one spike after which it is subjected to ionization in an atmospheric ion generator and processed by a mass spectrometer with the output of the mass spectrometer being processed by a microprocessor which through a controller coordinates operation of sample and spike delivery and equilibration as well as the operation of the atmospheric ion generator and mass spectrometer. The method may in the alternative be employed qualitatively.

REFERENCES:
patent: 4132605 (1979-01-01), Tench et al.
patent: 4324621 (1982-04-01), Kerby
patent: 4479852 (1984-10-01), Bindra et al.
patent: 4917777 (1990-04-01), Fisher
patent: 4975328 (1990-12-01), Hirose et al.
patent: 5012052 (1991-04-01), Hayes
patent: 5182131 (1993-01-01), Hashimoto et al.
patent: 5192403 (1993-03-01), Chang et al.
patent: 5352893 (1994-10-01), Freedman
patent: 5414259 (1995-05-01), Kingston
patent: 5572024 (1996-11-01), Gray et al.
patent: 5696378 (1997-12-01), Busch et al.
patent: 5703360 (1997-12-01), Fischer et al.
patent: 5872357 (1999-02-01), Flanagan
patent: 6032513 (2000-03-01), Chorush et al.
patent: 6280602 (2001-08-01), Robertson
patent: 6486469 (2002-11-01), Fischer et al.
patent: WO 99/39198 (1999-08-01), None
Fassett et al.,Determination of Nanogram Quantities of Vanadium in Biological Material by Isotope Dilution Thermal Ionization Mass Spectrometry with Ion Counting Detection, Anal. Chem. (Nov. 1985), pp. 2474-2478, V57, No. 13.
Fassett et al.,Isotope Dilution Mass Spectrometry for Accurate Elemental Analysis, Anal. Chem. (May 15, 1989), pp. 643A-649A V61, No. 10.
Viezian et al.,On-line Isotope Dilution and Sample Dilution by Flow Injection and Inductively Coupled Plasma Mass Spectrometry, J. Anal. Atom. Spectro. (Apr. 1990), pp. 125-133, V5.
Rottmann et al.,Determination of Heavy Metal Interactions with Dissolved Organic Materials in Natural Aquatic Systems by Coupling a High-Performance Liquid Chromatography System with an Inductively Coupled Mass Spectrometer, Anal. Chem. (Nov. 1, 1994), pp. 3709-3715, V66.
Heumann et al.,Elemental Speciation with Liquid Chromatography-Inductively Coupled Plasma Isotope Dilution Mass Spectrometry, J. Anal. Atom. Spectro. (Dec. 1994), pp. 1351-1355 V9.
Horn et al.,Comparison of heavy metal analyses in hydrofluoric acid used in microelectronic industry by ICP-MS and thermal ionization isotope dilution mass spectrometry, Fresenius J. Anal. Chem (1994), pp. 286-292, V350.
Rottmann et al.,Development of an on-line isotope dilution technique with HPLC/ICP-MS for the accurate determination of elemental species, Fresenius J. Anal Chem. (1994), pp. 221-227, V350.
Cole,Electrospray Ionization Mass Spectrometry: Fundamentals, Instrumentation and Applications, John Wiley & Sons, Inc. (1997), New York.
Stewart,Electrospray mass spectrometry: a tool for elemental speciation, Spectrochimica, Acta. (1999), pp. 1649-1695, Part-B, vol. 54.
International Technology Roadmap for Semiconductors 1999 Edition: Defect Reduction, Sematech, Austin, TX, pp. 269-293.
Newton et al.,Analysis of Copper Planting Baths—Suppressors and Levelers, Electrochemical Society Proceedings, pp. 1-5, V2000-27.
Applications of Isotope Dilution-Mass Spectrometry in Clinical Chemistry, Pharmacokinetics and Toxicology, Mass Spectrometry Reviews, pp 249-307 (1992).

Affiliated with

Also associated with

Rating

Automated in-process ratio mass spectrometry does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Automated in-process ratio mass spectrometry, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Automated in-process ratio mass spectrometry will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3479644