Automated electrophoresis and fluorescence detection apparatus a

Details Automated electrophoresis and fluorescence detection apparatus a Automated electrophoresis and fluorescence detection apparatus a

1994-12-12

1998-01-20

Font, Frank G.

Optics: measuring and testing

By electrophoresis

204461, 204466, 204612, G01N 2100

Patent

active

057106282

ABSTRACT:
Improved detection methods and apparatus which may be used individually or in various combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated.

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