Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1977-03-04
1978-08-22
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 23253R, 424 12, A61K 4300, G01N 3316, G01N 2300
Patent
active
041089766
ABSTRACT:
Automated radioimmunoassay directly from serum, for those antigens present in serum in relatively small amounts, is accomplished by use of an immobilized immunoadsorbent having an excess of antibodies, specific to the antigen, covalently bonded to a particulate substrate. The serum is diluted and preincubated in the presence of a radioactive labelled antigen and an antibody specific to the antigen. The preincubated mixture is flowed through the immobilized immunoadsorbent and the labelled and unlabelled antigen not bound to the antibody in preincubation are bound to the immobilized immunoadsorbent while the labelled and unlabelled antigen bound to the antibody during preincubation flow through the immunoadsorbent. An eluting solution is flowed through the immunoadsorbent to release the antigens bound thereto for reuse of the immunoadsorbent. By counting the radioactivity of one or both the fractions which flow through the immunoadsorbent or which is released therefrom, the quantity of a specific antigen in the serum may be assayed.
REFERENCES:
patent: 3896217 (1975-07-01), Johnson
patent: 3940475 (1976-02-01), Gross
patent: 3950134 (1976-04-01), Miles
patent: 3950643 (1976-04-01), Charlton
patent: 3989383 (1976-11-01), Paulson
patent: 4009005 (1977-02-01), Johnson
patent: 4022577 (1977-05-01), Brooker
Becton Dickinson and Company
Martella Mario A.
Nucker Christine M.
Padgett Benjamin R.
LandOfFree
Automated direct serum radioimmunoassay does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Automated direct serum radioimmunoassay, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Automated direct serum radioimmunoassay will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1558452