Automated direct serum radioassay

Details Automated direct serum radioassay Automated direct serum radioassay

1978-06-30

1981-05-19

Schafer, Richard E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 422 71, 424 12, G01N 3316, A61K 4300

Patent

active

042684943

ABSTRACT:
Automated radioassay in which a serum is diluted and pre-incubated in the presence of a radioactive labeled ligand, such as an antigen, and a binder, such as an antibody, specific to the ligand. The pre-incubated mixture is flowed through a chamber containing binder specific to the ligand supported on a solid support, and the labeled and unlabeled ligand not bound to the binder in pre-incubation are bound to the receptor on flow through the chamber. An eluting solution is flowed through the chamber to release the ligand bound to the binder in the chamber for reuse thereof. By counting the radioactivity of one or both of the fraction which flows through the chamber or which is subsequently released therefrom the quantity of a specific ligand in the serum may be assayed.

REFERENCES:
patent: 3896217 (1975-07-01), Johnson
patent: 3940475 (1976-02-01), Gross
patent: 3950134 (1976-04-01), Miles
patent: 3950643 (1976-04-01), Charlton
patent: 3989383 (1976-11-01), Paulson
patent: 4009005 (1977-02-01), Johnson
patent: 4022577 (1977-05-01), Brooker
patent: 4108976 (1978-08-01), Reese

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