Automated determining and measuring device and method

Chemistry: analytical and immunological testing – Automated chemical analysis

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422 63, 422 65, 422 67, 422 681, 422100, 422 8208, 436 47, 436 48, 436 49, 436 50, 436164, 436172, 436174, 436180, G01N 3500

Patent

active

061501735

ABSTRACT:
The invention relates to an automated device for determining or identifying and measuring a random number of different molecular classes, molecular parts or molecular groups in liquid or solid objects, in particular in cells and tissue specimen, said device comprising a combination of a pipetting system, a 3D handling system and an optical measuring system, preferably a microscope stand including an imaging device.
The invention further relates to an automated method for determining or identifying and mapping a random number of molecular classes, molecular parts and molecular groups in objects, with which a random number of different reagent solutions may be applied simultaneously or sequentially to a liquid or solid object, in particular a cell, cells or a tissue specimen, and measured. An important field of application of the invention is cancer research as well as research into the immune system. Within a very short time, precise evaluation results as to quantity as well as quality are obtained concerning the arrangement and correlative distribution of the molecular species in the object under examination. These results may for example give an insight into various diseases and their treatment.

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Confocal Spectral imaging analysis in studies of the spatial distribution of antiumour drugs within living cancer cells-Elsevier Science B.V. -1994.

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