Automated detection of platelets and reticulocytes in whole bloo

Details Automated detection of platelets and reticulocytes in whole bloo Automated detection of platelets and reticulocytes in whole bloo

1980-08-15

1982-04-20

Serwin, Ronald

Chemistry: physical processes

Physical processes

Crystallization

356 39, 424 3, G01N 130, G01N 2125, G01N 3350

Patent

active

043257062

ABSTRACT:
A sample of whole blood is stained with an acridine orange reagent, and is analyzed rapidly, a cell at a time, in a flow cytometry system having a sample stream dimension in the range of expected red cell dimensions. Red florescence and forward scatter data is utilized first to discriminate a cell from noise, and then to distinguish platelets from reticulocytes and red cells. The red cell and reticulocyte data is subjected to a correction such as rotational coordinate shift, and the shifted data are, by means of statistical procedures, utilized to determine threshold criteria separating red cells from reticulocytes, and to enumerate the cells on that basis.

REFERENCES:
patent: 3781112 (1973-12-01), Groner et al.
patent: 3883247 (1975-05-01), Adams
patent: 3896307 (1975-07-01), Trowe
patent: 3919530 (1975-11-01), Cheng
patent: 3989382 (1976-11-01), Kent et al.
patent: 4000417 (1976-12-01), Adkisson et al.
patent: 4219440 (1980-08-01), Runck et al.

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