Chemical apparatus and process disinfecting – deodorizing – preser – Chemical reactor – Bench scale
Reexamination Certificate
1999-11-23
2003-03-18
Soderquist, Arlen (Department: 1743)
Chemical apparatus and process disinfecting, deodorizing, preser
Chemical reactor
Bench scale
C422S063000, C422S065000, C422S067000, C422S081000, C422S091000, C422S105000, C422S105000, C422S105000, C422S105000, C422S105000, C422S129000, C436S043000, C436S049000
Reexamination Certificate
active
06534019
ABSTRACT:
CROSS-REFERENCE TO RELATED APPLICATIONS
The present application claims priority under 35 U.S.C. §119 to Japanese Patent Application No. 10-366,952, filed Dec. 24, 1998, entitled “Automated Synthesizing Apparatus.” The contents of that application are incorporated herein by reference in their entirety.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to an automated chemical synthesizer which includes a mechanism configured to prevent the diffusion of gas which is produced when compounds are collected.
2. Description of the Background
Automated chemical synthesizers have been used for research in the fields of pharmaceutical, life science, chemistry and material science among others.
FIGS. 13 and 14
show a conventional automated chemical synthesizer. Referring to
FIGS. 13 and 14
, the automated chemical synthesizer has a syringe
53
and a reaction block
51
including multiple reaction vessels
52
in which synthetic reactions take place. The syringe
53
dispenses solvents and reagents to the reaction vessels
52
according to preset dispensing protocols. Furthermore, in the automated chemical synthesizer, synthetic reactions in the reaction vessels
52
take place in parallel. Therefore, the automated chemical synthesizer synthesizes multiple experimental chemical compounds simultaneously. Then, compounds synthesized in the reaction vessels
52
are collected respectively.
The automated chemical synthesizer includes a collecting block
54
which holds a number of collection vessels
55
. Chemical compounds synthesized in the reaction vessels
52
are collected in the collection vessels
55
. The collection vessels
55
are provided in the same manner as the reaction vessels
52
. The number of the collection vessels
55
is same as that of the reaction vessels
52
. To collect synthesized chemical compounds, the collecting block
54
rises until the top portions of the collection vessels
55
contact with the lower surface of the reaction block
51
. The collecting block
54
is set below the reaction block
51
so that the collection vessels
55
communicate with the reaction vessels
52
. Hence, the compounds are transferred from the reaction vessels
52
into the collection vessels
55
.
However, in this automated chemical synthesizer, gas which is produced when compounds are synthesized and collected may leak from a gap created between the lower surface of the reaction block
51
and the top portions of the collection vessels
55
. The gas is sometimes harmful.
For instance, in a synthesis involving a solid phase reaction, synthesized chemical compounds are produced in resin granules and thus are extracted by a solvent, usually a strong acid such as Tri-Fluoroacetate (“TFA”). In the conventional automated chemical synthesizers, the harmful gas from such a solvent could leak from the gap between the reaction vessels and the collection vessels, and diffuse into the chemical synthesizer. The gas could not only corrode the chemical synthesizer but also harm the people around it.
SUMMARY OF THE INVENTION
An object of the present invention is to provide an automated chemical synthesizer which includes a mechanism configured to prevent the diffusion of gas which is produced when synthesized compounds are collected.
This object is achieved according to the present invention by providing a novel automated chemical synthesizer including at least one reaction vessel, at least one collection vessel, a passage and a gas discharging unit. A compound is to be synthesized in the at least one reaction vessel. The at least one collection vessel is configured to be connected to the at least one reaction vessel in order to collect the compound from the at least one reaction vessel. The passage is configured to communicate with the at least one collection vessel. The gas discharging unit is provided in the passage and configured to discharge gas from the at least one collection vessel through the passage.
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Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Quan Elizabeth
Shimadzu Corporation
Soderquist Arlen
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