Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1997-05-07
2000-02-22
Redding, David A.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204602, 204603, G01N 2726
Patent
active
06027624&
ABSTRACT:
The automated capillary electrophoresis method and apparatus analyzes a sample in real time or near real time in order to identify the presence of a number of different ions as well as other sample parameters, such as the relative concentrations of each ion identified in the sample. By performing capillary electrophoresis in an automated fashion, the automated capillary electrophoresis method and apparatus may be configured to monitor a manufacturing process online with little, if any, input from the system operator. The automated capillary electrophoresis method and apparatus also provides a base line such that the analysis results can be compared and can be more meaningfully interrupted. The automated capillary electrophoresis method and apparatus initially performs capillary electrophoresis upon a sample containing at least one ion to obtain data over time which relates to a predetermined property of the sample, such as the degree of transparency of at least a portion of the sample. This time dependent data is then automatically processed to determine one or more sample parameters. In this regard, the time dependent data is automatically processed to identify at least one peak within the data by determining those portions of the data which exceed a predetermined threshold. By separately determining the area under respective ones of the peaks, the capillary electrophoresis method and apparatus can automatically determine sample parameters, including the concentrations of the ions corresponding to the respective peaks.
REFERENCES:
patent: 5599433 (1997-02-01), Keo et al.
Altria, K.D. and Simpson, C.F., High Voltage Capillary Zone Electrophoresis: Operating Parameters Effects On Electroendosmotic Flows And Electrophoretic Mobilities, Chromatographia, vol. 24, 1987, pp. 527-32.
Bondoux, G., Jandik, P., and Jones, W.R., New approach to the analysis of low levels of anions in water, Journal of Chromatography, vol. 602, 1992, pp. 79-88.
Bruin, G.J.M., van Asten, A.C., et al, Theoretical and experimental aspects of indirect detection in capillary electrophoresis, Journal of Chromatography, vol. 608, 1992, pp. 97-107.
Brumley, W. C., Qualitative analysis of environmental samples for aromatic sulfonic acids by high-performance capillary electrophoresis, Journal of Chromatography, vol.603, 1992, pp. 267-272.
Buchberger, W. and Haddad, P.R., Effects of carrier electrolyte composition on separation selectivity in capillary zone electrophoresis of low-molecular-mass anions, Journal of Chromatography, vol. 608, 1992, pp. 59-64.
Hjerten, S., Elenbring, K., et al, Carrier-Free Zone Electrophoresis, Displacement Electrophoresis and Isoelectric Focusing in a High-Performance Electrophoresis Apparatus, Journal of Chromatography, vol. 403, 1987, pp. 47-61.
Jackson, P.E. and Haddad, P.R., Capillary electrophoresis of inorganic ions and low-molecular-mass ionic solutes, Trends in Analytical Chemistry, vol. 12, No. 6, 1993, pp. 231-238.
Jackson, P.E. and Haddad, P.R., The Occurrence and Origin of System Peaks in Non-Suppressed Ion Chromatography of Inorganic Anions with Indirect Ultraviolet Absorption Detection, Journal of Chromatography, vol. 346, 1985, pp. 125-137.
Jandik, P. and Jones, W.R., Optimization of detection sensitivity in the capillary electrophoresis of inorganic anions, Journal of Chromatography, vol. 546, 1991, pp. 431-443.
Jones, W.R. and Jandik, P., Various approaches to analysis of difficult sample matrices of anions using capillary ion electrophoresis, Journal of Chromatography, vol. 608, 1992, pp. 385-393.
Jones, W.R. and Jandik, P., New Methods for chromatographic separations of anions, American Laboratory, Jun. 1990, pp. 51-64.
Jones, W.R. and Jandik, P., Controlled changes of selectivity in the separation of ions by capillary electrophoresis, Journal of Chromatography, vol. 546, 1991, pp. 445-458.
Morin, Ph., Villard, F., Dreux, M., Short Communication: Borate complexation of flavonoid-O-glycosides in capillary electrophoresis, Journal of Chromatography, vol. 628, 1993, pp. 161-169.
Nair, J.B. and Izzo, C.G., Anion screening for drugs and intermediates by capillary ion electrophoresis, Journal of Chromatography, vol. 640, 1993, pp. 445-461.
Nielen, M.W.F., Indirect time-resolved luminescence detection in capillary zone electrophoresis, Journal of Chromatography, vol. 608, 1992, pp. 85-92.
Romano, J.P. and Krol, Jim, Capillary ion Electrophoresis, An Environmental Method for the Determination of Anions in Water, Journal of Chromatography, vol. 640, 1993, pp. 403-412.
Salomon, D.R. and Romano, Joe, Applications of Capillary Ion Electrophoresis in the Pulp and Paper Industry, Journal of Chromatography, vol. 602, 1992, pp. 219-225.
Weston, A., Brown, P.R., et al, Effect of electrolyte composition on the separation of inorganic metal cations by capillary ion electrophoresis, Journal of Chromatography, vol. 602, 1992, pp. 249-256.
Anderson Shawn
Asouzu Moore Ugochukwu
Redding David A.
Troy State University
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