Autologous plasma delipidation using a continuous flow system

Details Autologous plasma delipidation using a continuous flow system Autologous plasma delipidation using a continuous flow system

1988-01-20

1990-01-23

Truluck, Dalton L.

Surgery

Blood drawn and replaced or treated and returned to body

210645, 210651, 422 44, A61M 103

Patent

active

048955582

ABSTRACT:
A method and apparatus for autologous plasma delipidation of animals (including humans). The method comprises drawing blood from the animal, separating the plasma from the red blood cells, delipidating the plasma with a lipid solvent, remixing the delipidated with the red blood cells and re-introducing the delipidated blood into the animal. A preferred apparatus which utilizes the above method comprises a needle for drawing blood from the animal and the blood is then fed into a centrifugal separator where the blood is separated into the plasma and red blood cells. The plasma is then mixed with a biphase solvent and passed through a separator where the delipidated plasma (in an aqueous phase) is drawn off from the lipid components (in an organic phase). After removal of solvent, the delipidated plasma is remixed with the red blood cells and re-introduced to the animal by a re-infusion needle.

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patent: 4696670 (1987-09-01), Ohnishi et al.
Agnese et al.; "Evaluation of Four Reagents for Delipidation of Serum"; Clinical Biochemistry (Ottawa), 16(2), pp. 98-100 (1983).
Parker et al.; "Plasma HDL is Increased when LDL is Lowered by LDL-Pheresis"; Proc. Nat. Acad. Sci. (USA); 83(3), pp. 777-781 (2-1986).

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