Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Reexamination Certificate
2005-08-30
2005-08-30
Swartz, Rodney P (Department: 1645)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
C424S184100, C424S234100, C424S260100, C435S243000, C435S253300, C435S874000, C435S875000, C540S202000, C540S364000, C540S451000, C540S454000, C540S463000, C548S124000, C549S321000, C549S323000
Reexamination Certificate
active
06936447
ABSTRACT:
Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, forPseudomonas aeruginosaare described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection byPseudomonas aeruginosa.
REFERENCES:
patent: 4650750 (1987-03-01), Giese
patent: 4709016 (1987-11-01), Giese
patent: 5239088 (1993-08-01), Hoffman et al.
patent: 5320805 (1994-06-01), Kramer et al.
patent: 5536750 (1996-07-01), DeSolms et al.
patent: 5591872 (1997-01-01), Pearson et al.
patent: 5593827 (1997-01-01), Bycroft et al.
patent: 5686472 (1997-11-01), Anthony et al.
patent: 5776974 (1998-07-01), Bycroft et al.
patent: 6020121 (2000-02-01), Bao et al.
patent: WO 92/18614 (1992-10-01), None
patent: WOX 96/29392 (1996-09-01), None
patent: WOX 97/27851 (1997-08-01), None
Bainton, et al., “A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis inErwinia,” Gene, 1992, vol. 116, 87-91.
Bainton, et al., “N-(3-Oxohexanoyl)-L-homoserine lactose regulates carbapenem antibiotic production inErwina carotovora,”, Biochemistry Journal, 1992, vol. 288, 997-1004.
Bever, et al., “Molecular Characterization and Nucleotide Sequence of thePseudomas aeruginosaElastase Structural Gene,”Journal of Bacteriology, 1988, vol. 170, No. 9, 4309-4314.
Cao, et al., “Biosynthesis and Stereochemistry of the Autoinducer Controlling Luminescence inVibrio harveyi,” Journal of Bacteriology, 1993, vol. 175, No. 12, 3856-3862.
Cao, et al., “Purification and Structural Identification of an Autoinducer for the Luminescence System ofVibrio harveyi,”Journal of Biological Chemistry, 1989, vol. 264, No. 36, 21670-21676.
Choi, et al., “Genetic Dissection of DNA Binding and Luminescence Gene Activation by theVibrio fischeriLuxR Protein,”Journal of Bacteriology, 1992, vol. 174, No. 12, 4064-4069.
Eberhard, et al., “Analogs of the autoinducer of bioluminescence inVibrio fischeri,” Archives of Microbiology, 1986, vol. 146, No. 35, 35-40.
Eberhard, et al., “Structural Identification of Autoinducer ofPhotobacterium fischeriLuciferase,”Biochemistry, 1981, vol. 20, 2444-2449.
Eberhard, et al., “Synthesis of the lux gene autoinducer inVibrio fischeriis positively autoregulated,”Archives of Microbiology, 1991, vol. 155, 294-297.
Gambello and Iglewski, “Cloning and Characterization of thePseudomonas aeruginosalasR Gene, a Transcriptional Activator of Elastase Expression,”Journal of Bacteriology, 1991, vol. 173, No. 9, 3000-3009.
Goswami, et al., “Microbial Hydroxylation of Quadrone to 8a-Hydroxyquadrone,”Journal of Natural Products, 1987, vol. 50, No. 1, 49-54.
Hoiby, “Pseudomonas aeruginosaInfection in Cystic Fibrosis,”Acta. Path. Microbiol. Scand. Sect. B., 1974, vol. 82, 551-558.
Iglewski and Kabat, “NAD-Dependent Inhibition of Protein Synthesis byPseudomonas aeruginosaToxin,”PNAS, 1975, vol. 72, 2284-2288.
Iglewski, et al., “Pseudomonas aeruginosaexoenzyme S: An adenosine diphosphate ribosyltransferase distinct from toxin A,”PNAS1978, vol. 75, No. 7, 3211-3215.
Jones, et al., “The lux autoinducer regulates the production of exoenzyme virulence inErwinia carotovoraandPsuedomonas aeruginosa,” EMBO Journal, 1993, vol. 12, No. 6, 2477-2482.
Kaplan and Greenberg, “Diffusion of Autoinducer Is Involved in Regulation of theVibrio fischeriLuminescence System,”Journal of Bacteriology, 1985, vol. 163. 1210-1214.
Kessler and Safrin, “Synthesis, Processing and Transport ofPseudomonas aeruginosaElastase,”Journal of Bacteriology, 1988, vol. 170, No. 11, 5241-5247.
Meighen, “Molecular Biology of Bacterial Bioluminescence,”Microbiological Reviews, 1991, vol. 55, No. 1, 123-142.
Nicas and Iglewski, “The Contribution of exoproducts to virulence ofPseudomonas aeruginosa, ” Canadian Journal of Microbiology, 1985, vol. 31, No. 4, 387-392.
Passador, et al., “Expression ofPseudomas aeruginosaVirulence Genes Requires Cell-to-Cell Communication,”Science, 1993, vol. 260, 1127-1130.
Pearson, et al., “Structure of the autoinducer require for expression ofPseudomonas aeruginosavirulence genes,”PNAS USA, 1994, vol. 91, No. 1, 197-201.
Piper, et al., “Conjugation factor ofAgrobacterium tumefaciensregulates Ti plasmid transfer by autoinduction,”Nature, 1993, vol. 362, 448-450.
Pirhonen, et al., “A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogenErwinia carotovora,” EMBO Journal, 1993, vol. 12, No. 6, 2467-2476.
Railing, et al., “Growth rate-dependent regulation of RNA polymerase synthesis inEscherichia coli,” Mol. Gen. Genet., 1985, vol. 201, 379-386.
Reynolds, et al., “Pseudomonas aeruginosaInfections: Persisting Problems and Current Research to Find New Therapies,”Annals of Internal Medicine, 1975, vol. 82, No. 6, 819-831.
Stewart, et al., “Shedding New Light On Food Microbiology,”ASM News, 1993, vol. 59, No. 5, 241-247.
Wierenga and Skulnick, “General, Efficient, One-Step Synthesis of β-Keto Esters,”Journal of Organic Chemistry, 1979, vol. 44, No. 2, 310-311.
Williams, et al., “Small molecule-mediated density-dependent control of gene expression in prokaryotes: Bioluminescence and the biosynthesis of carbapenem antibiotics,”FEMS Microbiology, 1992, vol. 100, 161-168.
Zhang, et al., “Agrobacteriumconjugation and gene regulation by N-acyl-L-homoserine lactones,”Nature, 1993, vol. 362, 446-448.
Allison, D.G. et al., “A staining technique for attached bacteria and its correlation to extracellular carbohydrate production,”J. Microbiol. Methods, 2:93-99 (1984).
Allison, D.G. et al., “The role of polysaccharides in adhesion of freshwater bacteria,”J. Gen. Microbiol.,133:1319-1327 (1987).
Anwar, H. et al., “Dynamic interactions of biofilms on mucoidPseudomonas aeruginosawith tobramycin and piperacillin,”Antimicrob. Agents Chemother., 36:1208-1214 (1992).
Beck von Bodman, B.S. et al., “Capsular polysaccharide biosynthesis and pathogenicity inErwina carotovora,” J. Bacteriol., 177:5000-5008 (1995).
Boivin, J. et al., Biofilms and biodeterioration. In Biodeterioration and biodegradation 8 (ed.) H.W. Rossmore,Elsevier Applied Science, London, p. 53-62 (1991).
Boyd, A. et al., “Sequence of the algL gene ofPseudomonas aeruginosaand purification of its alginate lyase product,”Gene,131:1-8 (1993).
Boyd, A. et al., “Role of the alginate lyase in cell attachment ofPseudomonas aeruginosa,” Appl. Environ. Microbiol., 60:2355-2359 (1994).
Brint, J.M. et al., “Synthesis of multiple exoproducts inPseudomonas aeruginosais under the control of RH1R-Rh1I. Another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family,”J. Bacteriol., 177:7155-7163 (1995).
Christensen, B.E. et al., “Physical and chemical properties of biofilms,” In: Characklis, W.G. et al (eds.) Biofilms. John Wiley & Sons, New York, pp. 93-130 (1990).
Cohen-Bazire, G. et al., “Kinetic studies of pigment synthesis by non-sulfur purple bacteria,”J. cell. Comp. Physiol., 49:25-68 (1957).
Costerton, J.W. et al., “Bacterial biofilms in nature and disease,”Ann. Rev. Microbiol., 41:435-464 (1987).
Davies, D.G. et al., “Exopolysacchairde production in biofilms. Substratum activation of alginate gene expression byPseudomonas aeruginosa,” Appl. Environ. Microbiol., 59:1181-1186 (1993).
Davies, D.G. et al., “Regulation of the alginate biosynthesis gene algC inPseudomonas aeruginosaduring biofilm development in continuous culture,&#
Eberhard Anatol
Gray Kendall M.
Greenberg Everett P.
Iglewski Barbara H.
Passador Luciano
Hanley, Esq. Elizabeth A.
Ithaca College
Lahive & Cockfield LLP
Smith, Esq. DeAnn F.
Swartz Rodney P
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