Autoinducer molecule

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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435 4, C07D30733

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055918727

ABSTRACT:
Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.

REFERENCES:
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Jie-Gang Cao et al. "Purification and Structural Identification of an Autoinducer for the Luminescence System of Vibro harveyi*" Journal of Biological Chemistry, 1989, vol. 264, No. 36, pp. 21670-21676.
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Bainton et al. "N-(3-Oxohexanoyl)-L-homoserine lactose regulates carbapenem antibiotic production in Erwinia carotovora" Biochemistry Journal, 1992, vol. 288, pp. 997-1004.

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