Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2002-11-19
2008-08-12
Helms, Larry R. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S387200, C530S388150, C530S388220, C435S070210
Reexamination Certificate
active
07411045
ABSTRACT:
Disclosed herein are antitumor compositions and methods of interfering with the biological activity of PC cell derived growth factor (PCDGF), anti-PCDGF receptor antibodies, fragments thereof, and methods of making anti-PCDGF receptor antibodies. The methods involve inhibiting the proliferation of tumor cells expressing the PCDGF receptor by contacting the surface of the cell with anti-PCDGF receptor antibodies. Anti-PCDGF receptor antibodies are capable of binding to the surface of a cell and interfering with the binding of PCDGF to its receptor. Also provided are compositions comprising anti-PCDGF receptor antibodies and cytotoxic molecules (e.g., toxins, oncotoxins, mitotoxins, immunotoxins, and antisense oligonucleotides).
REFERENCES:
patent: 5709858 (1998-01-01), Godowski et al.
patent: 5869045 (1999-02-01), Hellstrom et al.
patent: 2005/0175616 (2005-08-01), Kiener et al.
patent: 2007/0065887 (2007-03-01), Kinch
patent: WO 91/15510 (1991-10-01), None
patent: WO 98/52607 (1998-11-01), None
patent: WO 02/31198 (2002-04-01), None
patent: WO 2005/000207 (2005-01-01), None
Kanno et al, Oncogene 20: 2138-2146, 2000.
Runqing Lu, et al.—“Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468,” PNAS, vol. 97, No. 8, Apr. 11, 2000, pp. 3993-3998.
Vijay Bhandari, et al.—“Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains,” Proc. Natl. Acad. Sci. USA, vol. 89, Mar. 1992, pp. 1715-1719.
Zhiheng He, et al.—“ProgranulinGene Expression Regulates Epithelial Cell Growth and Promotes Tumor Growthin Vivo1,” Can Cer Research 59, Jul. 1, 1999, pp. 3222-3229.
Haidi Zhang, et al.—“Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense CDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor),” Proc. Natl. Acad. Sci, USA, vol. 95, Nov. 1998, pp. 14202-14207.
International Search Report dated May 13, 2003.
Y. Shechter, et al.—“Mouse Antibodies to the Insulin Receptor Developing Spontaneously As Anti-idiotypes,” The Journal of Biological Chemistry, vol. 259, No. 10, pp. 6411-6415, 1984.
I. R. Cohan, et al.—“Production and Properties of Anti-idiotypic Antibodies That Recognize Insulin Receptor,” Methods in Enzymology, vol. 178, pp. 300-313, 1989.
Ran Hu, et al.—“Production and characterization of monoclonal anti-idiotypic antibody exhibiting a catalytic activity similar to carboxypeptidase A,” Journal of Biotechnology 61, 1998, pp. 109-115.
Y. Shechter, et al.—“Autoantibodies to Insulin Receptor Spontaneously Develop as Anti-Idiotypes in Mice Immunized with Insulin,” Science, vol. 216, Apr. 1982, pp. 542-545.
B. Avalle, et al.—“Functional mimicry: elicitation of a monoclonal anti-idiotypic antibody hydrolyzing β-lactams,” The FASEB Journal, vol. 12, Aug. 1998, pp. 1055-1061.
A. Kolesnikov, et al.—“Enzyme mimicry by the antiidiotypic antibody approach,” PNAS, vol. 97, No. 25, Dec. 2000, pp. 13526-13531.
A.D. Strosberg—“Interaction of Anti-idiotypic Antibodies with Membrane Receptors: Practical Considerations,” Methods of Enzymology, vol. 178, pp. 178-265 plus Table of Contents, 1989.
S. W. Bright, et al.—“Monoclonal Antibodies As Surrogate Receptors In A High Throughput Screen For Compounds That Enhance Insulin Sensitifity,” Life Sciences, vol. 61, No. 23, 1997, pp. 2305-2315.
C. Monfardini, et al.—“Recombinant Antibodies in Bioactive Peptide Design (*),” vol. 270, No. 12, Issue of Mar. 1995, The American Society for Biochemistry and Molecular Biology, pp. 6628-6638.
“The Study of Antibody Recognition,” Antibody Resource Page, Feb. 1998, 10 pages.
Zhang Haidi, “Overexpression of PC cell derived growth factor (PCDGF) contributes to the highly tumorigenic properties of producer cell line PC,” DISS. ABSTR. INT>, vol., 58, No. 11, 1998, p. 5814-B XP001025915, abstract.
Vijay Bhandari and Andrew Bateman, “Structure and Chromosomal Location of the human granulin gene,” Biochemical and Biophysical Research Communications, vol. 188, No. 1, Oct. 1992, pp. 57-63, XP001018991, abstract.
Bhandari et al. - “The Complementary Deoxyribonucleic Acid Sequence, Tissue Distribution, and Cellular Localization of the Rat Granulin Precursor,” Endocrinology, vol. 133, No. 6, Oct. 1993, pp. 2682-2689, XP001021601.
Plowman et al. - “The Epithelin Precursor Encodes Two Proteins With Opposing Activities on Epithelial Cell Growth,” Journal of Biological Chemistry, vol. 267, No. 18, Jun. 1992, pp. 13073-13078, XP001018992.
Effect of Testosterone on the Growth Properties and on Epidermal Growth Factor Receptor Expression in the Teratoma-derived Tumorigenic Cell Line 1246-3A, Serrero, G. et al., Cancer Research 52, 1992, pp. 4242-4247.
Molecular Biology of the Cell, Alberts, B., et al., Garland Publishing, Inc., 1983.
Growth Factors in Development, Transformation, and Tumorigenesis, Cross, M. et al., Cell, vol. 64, 1991, pp. 271-280.
Autocrine Secretion and Malignant Transformation of Cells, Sporn, M.B. et al., The New England Journal of Medicine, vol. 303, 1980, pp. 878-880.
Purification of an Autocrine Growth Factor Homologous with Mouse Epithelin Precursor from a Highly Tumorigenic Cell Line, Zhou, J. et al., The Journal of Biological Chemistry, vol. 268, No. 15, 1993, pp. 10863-10869.
The Epithelin Precursor Encodes Two Proteins with Opposing Activities on Epithelial Cell Growth, Plowman, G. et al., The Journal of Biological Chemistry, vol. 267, No. 18, 1992, pp. 13073-13078.
Granulins, a Novel Class of Peptide from Leukocytes, Bateman, A. et al., Biochemical and Biophysical Research Communications, vol. 173, No. 3, 1990, pp. 1161-1168.
A Synthetic Fragment of Rat Transforming Growth Factor with Receptor Binding and Antigenic Properties, Nestor, J. et al., Biochemical and Biophysical Research Communications, vol. 129, No. 1, 1985, pp. 226-232.
In VitroDeletional Mutagenesis for Bacterial Production of the 20,000-Dalton Form of Human Pituitary Growth Hormone, Adelman, J. et al., DNA, vol. 2, No. 3, 1983, pp. 183-193.
AnIn VitroModel to Study Adipose Differentiation in Serum-Free Medium, Serrero, G. et al., Analytical Biochemistry 120, 1982, pp. 351-359.
Study of a Teratoma-Derived Adipogenic Cell Line 1246 and Isolation of an Insulin-Independent Variant in Serum-Free Medium, Serrero-Dave, G., Cancer Center, University of California, pp. 366-376.
Tumorigenicity Associated With Loss of Differentiation and of Response to Insulin in the Adipogenic Cell Line 1246, Serrero, G., IN Vitro Cellular & Development Biology, vol. 21, No. 9, 1985, pp. 537-540.
Decreased Transforming Growth Factor-β Response and Binding in Insulin-Independent Teratoma-Derived Cell Lines with Increased Tumorigenic Properties, Serrero, G. et al., Journal of Cellular Physiology, 149, 1991, pp. 503-511.
Growth Inhibition of Human Breast Cancer Cellsin Vitrowith an Antibody against the Type I Somatomedin Receptor, Arteaga, C. et al., Cancer Research 49, 1989, pp. 6237-6241.
The Biological Effects of a High Molecular Weight Form of IGF II in a Pluripotential Human Teratocarcinoma Cell Line, Schofield, P. et al., Anticancer Research 14, 1994, pp. 533-538.
Gene therapy of murine teratocarcinoma: Separate functions for insulin-like growth factors I and II in immunogenicity and differentiation, Trojan, J. et al., Proc. Natl. Acad. Sci. USA, vol. 91, 1994, pp. 6088-6092.
Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA, Trojan, J. et al., Science, vol. 259, 1993, pp. 94-96.
Continuous cultures of fused cells secreting antibody of predefined specificity, Kohler, G. et
Serrero Ginette
Sun Le
A&G Pharmaceutical, Inc.
Connolly Bove & Lodge & Hutz LLP
Halvorson Mark
Helms Larry R.
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